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Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides.
ChemMedChem. 2021 Jan 19;16(2):319-327. doi: 10.1002/cmdc.202000598. Epub 2020 Oct 28.
ChemMedChem. 2021.
PMID: 32926544
Free PMC article.
Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 ( AeKir1) Channel.
Aretz CD, Morwitzer MJ, Sanford AG, Hogan AM, Portillo MV, Kharade SV, Kramer M, McCarthey JB, Trigueros RR, Piermarini PM, Denton JS, Hopkins CR.
Aretz CD, et al.
ACS Infect Dis. 2019 Jun 14;5(6):917-931. doi: 10.1021/acsinfecdis.8b00368. Epub 2019 Mar 15.
ACS Infect Dis. 2019.
PMID: 30832472
Free PMC article.
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Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics.
Aretz CD, Vadukoot AK, Hopkins CR.
Aretz CD, et al.
J Med Chem. 2019 Oct 10;62(19):8682-8694. doi: 10.1021/acs.jmedchem.8b01891. Epub 2019 May 9.
J Med Chem. 2019.
PMID: 31034224
Review.
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Discovery, synthesis and biological characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators.
Sharma S, Lesiak L, Aretz CD, Du Y, Kumar S, Gautam N, Alnouti Y, Dhuria NV, Chhonker YS, Weaver CD, Hopkins CR.
Sharma S, et al. Among authors: aretz cd.
RSC Med Chem. 2021 Jun 21;12(8):1366-1373. doi: 10.1039/d1md00129a. eCollection 2021 Aug 18.
RSC Med Chem. 2021.
PMID: 34458739
Free PMC article.
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Synthesis and SAR Studies of 1H-Pyrrolo[2,3-b]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors.
Vadukoot AK, Sharma S, Aretz CD, Kumar S, Gautam N, Alnouti Y, Aldrich AL, Heim CE, Kielian T, Hopkins CR.
Vadukoot AK, et al. Among authors: aretz cd.
ACS Med Chem Lett. 2020 Jan 24;11(10):1848-1854. doi: 10.1021/acsmedchemlett.9b00369. eCollection 2020 Oct 8.
ACS Med Chem Lett. 2020.
PMID: 33062163
Free PMC article.
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Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1.
Sharma S, Peng Q, Vadukoot AK, Aretz CD, Jensen AA, Wallick AI, Dong X, Hopkins CR.
Sharma S, et al. Among authors: aretz cd.
ACS Med Chem Lett. 2022 Apr 19;13(5):841-847. doi: 10.1021/acsmedchemlett.2c00100. eCollection 2022 May 12.
ACS Med Chem Lett. 2022.
PMID: 35586421
Free PMC article.
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Mechanism of SmI2 Reduction of 5-Bromo-6-oxo-6-phenylhexyl Methanesulfonate Studied by Spin Trapping with 2-Methyl-2-nitrosopropane.
Aretz CD, McPeak JE, Eaton GR, Eaton SS, Cowen BJ.
Aretz CD, et al.
J Org Chem. 2018 Sep 7;83(17):10688-10692. doi: 10.1021/acs.joc.8b01517. Epub 2018 Aug 23.
J Org Chem. 2018.
PMID: 30102044
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