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Neutral ceramidase-active site inhibitor chemotypes and binding modes.
Coant N, Bickel JD, Rahaim R, Otsuka Y, Choi YM, Xu R, Simoes M, Cariello C, Mao C, Saied EM, Arenz C, Spicer TP, Bannister TD, Tonge PJ, Airola MV, Scampavia L, Hannun YA, Rizzo RC, Haley JD. Coant N, et al. Among authors: arenz c. Bioorg Chem. 2023 Oct;139:106747. doi: 10.1016/j.bioorg.2023.106747. Epub 2023 Jul 27. Bioorg Chem. 2023. PMID: 37531819 Free PMC article.
Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening.
Otsuka Y, Airola MV, Choi YM, Coant N, Snider J, Cariello C, Saied EM, Arenz C, Bannister T, Rahaim R Jr, Hannun YA, Shumate J, Scampavia L, Haley JD, Spicer TP. Otsuka Y, et al. Among authors: arenz c. SLAS Discov. 2021 Jan;26(1):113-121. doi: 10.1177/2472555220945283. Epub 2020 Jul 31. SLAS Discov. 2021. PMID: 32734807 Free PMC article.
Small molecule inhibitors of ceramidases.
Saied EM, Arenz C. Saied EM, et al. Among authors: arenz c. Cell Physiol Biochem. 2014;34(1):197-212. doi: 10.1159/000362995. Epub 2014 Jun 16. Cell Physiol Biochem. 2014. PMID: 24977492 Free article. Review.
Inhibitors of Ceramidases.
Saied EM, Arenz C. Saied EM, et al. Among authors: arenz c. Chem Phys Lipids. 2016 May;197:60-8. doi: 10.1016/j.chemphyslip.2015.07.009. Epub 2015 Jul 26. Chem Phys Lipids. 2016. PMID: 26220616 Review.
FRET probes for measuring sphingolipid metabolizing enzyme activity.
Mohamed ZH, Rhein C, Saied EM, Kornhuber J, Arenz C. Mohamed ZH, et al. Among authors: arenz c. Chem Phys Lipids. 2018 Nov;216:152-161. doi: 10.1016/j.chemphyslip.2018.09.014. Epub 2018 Sep 24. Chem Phys Lipids. 2018. PMID: 30261173 Review.
129 results