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CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.
Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM. Tabeling C, et al. Among authors: arenz c. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23. doi: 10.1073/pnas.1421190112. Epub 2015 Mar 17. Proc Natl Acad Sci U S A. 2015. PMID: 25829545 Free PMC article.
Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6.
Samapati R, Yang Y, Yin J, Stoerger C, Arenz C, Dietrich A, Gudermann T, Adam D, Wu S, Freichel M, Flockerzi V, Uhlig S, Kuebler WM. Samapati R, et al. Among authors: arenz c. Am J Respir Crit Care Med. 2012 Jan 15;185(2):160-70. doi: 10.1164/rccm.201104-0717OC. Am J Respir Crit Care Med. 2012. PMID: 22246702
Stimulation of the EP3 receptor causes lung oedema by activation of TRPC6 in pulmonary endothelial cells.
Jiang T, Samapati R, Klassen S, Lei D, Erfinanda L, Jankowski V, Simmons S, Yin J, Arenz C, Dietrich A, Gudermann T, Adam D, Schaefer M, Jankowski J, Flockerzi V, Nüsing R, Uhlig S, Kuebler WM. Jiang T, et al. Among authors: arenz c. Eur Respir J. 2022 Oct 13;60(4):2102635. doi: 10.1183/13993003.02635-2021. Print 2022 Oct. Eur Respir J. 2022. PMID: 35450969 Free article.
Small molecule inhibitors of ceramidases.
Saied EM, Arenz C. Saied EM, et al. Among authors: arenz c. Cell Physiol Biochem. 2014;34(1):197-212. doi: 10.1159/000362995. Epub 2014 Jun 16. Cell Physiol Biochem. 2014. PMID: 24977492 Free article. Review.
A photocaged inhibitor of acid sphingomyelinase.
Prause K, Naseri G, Schumacher F, Kappe C, Kleuser B, Arenz C. Prause K, et al. Among authors: arenz c. Chem Commun (Camb). 2020 Nov 26;56(94):14885-14888. doi: 10.1039/d0cc06661c. Chem Commun (Camb). 2020. PMID: 33179626
129 results