Arce FT - Search Results

1

Alzheimer's disease: which type of amyloid-preventing drug agents to employ?

Jang H, Connelly L, Arce FT, Ramachandran S, Lal R, Kagan BL, Nussinov R. Jang H, et al. Among authors: arce ft. Phys Chem Chem Phys. 2013 Jun 21;15(23):8868-77. doi: 10.1039/c3cp00017f. Epub 2013 Feb 28. Phys Chem Chem Phys. 2013. PMID: 23450150 Free PMC article. Review.

2

Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels.

Jang H, Arce FT, Capone R, Ramachandran S, Lal R, Nussinov R. Jang H, et al. Among authors: arce ft. Biophys J. 2009 Dec 2;97(11):3029-37. doi: 10.1016/j.bpj.2009.09.014. Biophys J. 2009. PMID: 19948133 Free PMC article.

3

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.

Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R. Jang H, et al. Among authors: arce ft. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6538-43. doi: 10.1073/pnas.0914251107. Epub 2010 Mar 22. Proc Natl Acad Sci U S A. 2010. PMID: 20308552 Free PMC article.

4

β-Barrel topology of Alzheimer's β-amyloid ion channels.

Jang H, Arce FT, Ramachandran S, Capone R, Lal R, Nussinov R. Jang H, et al. Among authors: arce ft. J Mol Biol. 2010 Dec 17;404(5):917-34. doi: 10.1016/j.jmb.2010.10.025. Epub 2010 Oct 21. J Mol Biol. 2010. PMID: 20970427 Free PMC article.

5

Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link.

Jang H, Arce FT, Mustata M, Ramachandran S, Capone R, Nussinov R, Lal R. Jang H, et al. Among authors: arce ft. Biophys J. 2011 Apr 6;100(7):1775-83. doi: 10.1016/j.bpj.2011.01.072. Biophys J. 2011. PMID: 21463591 Free PMC article.

6

Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology.

Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R. Connelly L, et al. Among authors: arce ft. J Phys Chem B. 2012 Feb 9;116(5):1728-35. doi: 10.1021/jp2108126. Epub 2012 Jan 25. J Phys Chem B. 2012. PMID: 22217000 Free PMC article.

7

Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane.

Jang H, Connelly L, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. Jang H, et al. Among authors: arce ft. J Chem Theory Comput. 2013 Jan 8;9(1):822-833. doi: 10.1021/ct300916f. Epub 2012 Dec 5. J Chem Theory Comput. 2013. PMID: 23316126 Free PMC article.

8

Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.

Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. Jang H, et al. Among authors: arce ft. J Phys Chem B. 2013 Oct 3;117(39):11518-29. doi: 10.1021/jp405389n. Epub 2013 Sep 13. J Phys Chem B. 2013. PMID: 24000923 Free PMC article.

9

Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.

Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. Jang H, et al. Among authors: arce ft. Chem Soc Rev. 2014 Oct 7;43(19):6750-64. doi: 10.1039/c3cs60459d. Chem Soc Rev. 2014. PMID: 24566672 Free PMC article. Review.

10

Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels.

Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R. Jang H, et al. Among authors: arce ft. Methods Mol Biol. 2016;1345:251-68. doi: 10.1007/978-1-4939-2978-8_16. Methods Mol Biol. 2016. PMID: 26453217 Free PMC article.

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