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A seeding-based neuronal model of tau aggregation for use in drug discovery.
Amorim IS, Challal S, Cistarelli L, Dorval T, Abjean L, Touzard M, Arbez N, François A, Panayi F, Jeggo R, Cecon E, Oishi A, Dam J, Jockers R, Machado P. Amorim IS, et al. Among authors: arbez n. PLoS One. 2023 Apr 4;18(4):e0283941. doi: 10.1371/journal.pone.0283941. eCollection 2023. PLoS One. 2023. PMID: 37014877 Free PMC article.
RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2.
Li PP, Moulick R, Feng H, Sun X, Arbez N, Jin J, Marque LO, Hedglen E, Chan HYE, Ross CA, Pulst SM, Margolis RL, Woodson S, Rudnicki DD. Li PP, et al. Among authors: arbez n. Mov Disord. 2021 Nov;36(11):2519-2529. doi: 10.1002/mds.28729. Epub 2021 Aug 14. Mov Disord. 2021. PMID: 34390268 Free PMC article.
Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics.
Akimov SS, Jiang M, Kedaigle AJ, Arbez N, Marque LO, Eddings CR, Ranum PT, Whelan E, Tang A, Wang R, DeVine LR, Talbot CC, Cole RN, Ratovitski T, Davidson BL, Fraenkel E, Ross CA. Akimov SS, et al. Among authors: arbez n. Hum Mol Genet. 2021 Nov 30;30(24):2469-2487. doi: 10.1093/hmg/ddab200. Hum Mol Genet. 2021. PMID: 34296279 Free PMC article.
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
Hegde RN, Chiki A, Petricca L, Martufi P, Arbez N, Mouchiroud L, Auwerx J, Landles C, Bates GP, Singh-Bains MK, Dragunow M, Curtis MA, Faull RL, Ross CA, Caricasole A, Lashuel HA. Hegde RN, et al. Among authors: arbez n. EMBO J. 2020 Sep 1;39(17):e104671. doi: 10.15252/embj.2020104671. Epub 2020 Aug 5. EMBO J. 2020. PMID: 32757223 Free PMC article.
Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease.
Jiang M, Zhang X, Liu H, LeBron J, Alexandris A, Peng Q, Gu H, Yang F, Li Y, Wang R, Hou Z, Arbez N, Ren Q, Dong JL, Whela E, Wang R, Ratovitski T, Troncoso JC, Mori S, Ross CA, Lim J, Duan W. Jiang M, et al. Among authors: arbez n. Hum Mol Genet. 2020 May 28;29(8):1340-1352. doi: 10.1093/hmg/ddaa061. Hum Mol Genet. 2020. PMID: 32242231 Free PMC article.
G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice.
Arbez N, He X, Huang Y, Ren M, Liang Y, Nucifora FC, Wang X, Pei Z, Tessarolo L, Smith WW, Ross CA. Arbez N, et al. Hum Mol Genet. 2020 Mar 13;29(4):580-590. doi: 10.1093/hmg/ddz271. Hum Mol Genet. 2020. PMID: 31813996 Free PMC article.
36 results