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Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces Cytokine Secretion in Epithelial and Stromal Cell Lines.
Vivas-Ruiz DE, Rosas P, Proleón A, Torrejón D, Lazo F, Tenorio-Ricca AB, Guajardo F, Almarza C, Andrades V, Astorga J, Oropesa D, Toledo J, Vera MJ, Martínez J, Araya-Maturana R, Dubois-Camacho K, Hermoso MA, Alvarenga VG, Sanchez EF, Yarlequé A, Oliveira LS, Urra FA. Vivas-Ruiz DE, et al. Among authors: araya maturana r. Pharmaceutics. 2023 May 18;15(5):1533. doi: 10.3390/pharmaceutics15051533. Pharmaceutics. 2023. PMID: 37242775 Free PMC article.
An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G₂/M-phase arrest in mammary adenocarcinoma TA3.
Urra FA, Martínez-Cifuentes M, Pavani M, Lapier M, Jaña-Prado F, Parra E, Maya JD, Pessoa-Mahana H, Ferreira J, Araya-Maturana R. Urra FA, et al. Toxicol Appl Pharmacol. 2013 Mar 15;267(3):218-27. doi: 10.1016/j.taap.2012.12.023. Epub 2013 Jan 17. Toxicol Appl Pharmacol. 2013. PMID: 23333614
Mitochondria: a promising target for anticancer alkaloids.
Urra FA, Cordova-Delgado M, Pessoa-Mahana H, Ramírez-Rodríguez O, Weiss-Lopez B, Ferreira J, Araya-Maturana R. Urra FA, et al. Curr Top Med Chem. 2013;13(17):2171-83. doi: 10.2174/15680266113139990150. Curr Top Med Chem. 2013. PMID: 23978135 Review.
Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation.
Urra FA, Córdova-Delgado M, Lapier M, Orellana-Manzano A, Acevedo-Arévalo L, Pessoa-Mahana H, González-Vivanco JM, Martínez-Cifuentes M, Ramírez-Rodríguez O, Millas-Vargas JP, Weiss-López B, Pavani M, Ferreira J, Araya-Maturana R. Urra FA, et al. Toxicol Appl Pharmacol. 2016 Jan 15;291:46-57. doi: 10.1016/j.taap.2015.12.005. Epub 2015 Dec 19. Toxicol Appl Pharmacol. 2016. PMID: 26712467
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.
Urra FA, Muñoz F, Córdova-Delgado M, Ramírez MP, Peña-Ahumada B, Rios M, Cruz P, Ahumada-Castro U, Bustos G, Silva-Pavez E, Pulgar R, Morales D, Varela D, Millas-Vargas JP, Retamal E, Ramírez-Rodríguez O, Pessoa-Mahana H, Pavani M, Ferreira J, Cárdenas C, Araya-Maturana R. Urra FA, et al. Sci Rep. 2018 Sep 4;8(1):13190. doi: 10.1038/s41598-018-31367-9. Sci Rep. 2018. PMID: 30181620 Free PMC article.
69 results