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SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients.
Jimenez-Vazquez EN, Arad M, Macías Á, Vera-Pedrosa ML, Cruz FM, Gutierrez LK, Cuttitta AJ, Monteiro da Rocha A, Herron TJ, Ponce-Balbuena D, Guerrero-Serna G, Binah O, Michele DE, Jalife J. Jimenez-Vazquez EN, et al. Among authors: arad m. Elife. 2022 Jun 28;11:e76576. doi: 10.7554/eLife.76576. Elife. 2022. PMID: 35762211 Free PMC article.
CRISPR correction of the PRKAG2 gene mutation in the patient's induced pluripotent stem cell-derived cardiomyocytes eliminates electrophysiological and structural abnormalities.
Ben Jehuda R, Eisen B, Shemer Y, Mekies LN, Szantai A, Reiter I, Cui H, Guan K, Haron-Khun S, Freimark D, Sperling SR, Gherghiceanu M, Arad M, Binah O. Ben Jehuda R, et al. Among authors: arad m. Heart Rhythm. 2018 Feb;15(2):267-276. doi: 10.1016/j.hrthm.2017.09.024. Epub 2017 Sep 14. Heart Rhythm. 2018. PMID: 28917552
Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy.
Schick R, Mekies LN, Shemer Y, Eisen B, Hallas T, Ben Jehuda R, Ben-Ari M, Szantai A, Willi L, Shulman R, Gramlich M, Pane LS, My I, Freimark D, Murgia M, Santamaria G, Gherghiceanu M, Arad M, Moretti A, Binah O. Schick R, et al. Among authors: arad m. PLoS One. 2018 Oct 17;13(10):e0205719. doi: 10.1371/journal.pone.0205719. eCollection 2018. PLoS One. 2018. PMID: 30332462 Free PMC article.
Modeling Peripartum Cardiomyopathy With Human Induced Pluripotent Stem Cells Reveals Distinctive Abnormal Function of Cardiomyocytes.
Naftali-Shani N, Molotski N, Nevo-Caspi Y, Arad M, Kuperstein R, Amit U, Huber I, Zeltzer LA, Levich A, Abbas H, Monserrat L, Paret G, Leor J. Naftali-Shani N, et al. Among authors: arad m. Circulation. 2018 Dec 4;138(23):2721-2723. doi: 10.1161/CIRCULATIONAHA.118.035950. Circulation. 2018. PMID: 30571272 No abstract available.
Electrophysiological abnormalities in induced pluripotent stem cell-derived cardiomyocytes generated from Duchenne muscular dystrophy patients.
Eisen B, Ben Jehuda R, Cuttitta AJ, Mekies LN, Shemer Y, Baskin P, Reiter I, Willi L, Freimark D, Gherghiceanu M, Monserrat L, Scherr M, Hilfiker-Kleiner D, Arad M, Michele DE, Binah O. Eisen B, et al. Among authors: arad m. J Cell Mol Med. 2019 Mar;23(3):2125-2135. doi: 10.1111/jcmm.14124. Epub 2019 Jan 8. J Cell Mol Med. 2019. PMID: 30618214 Free PMC article.
Depressed β-adrenergic inotropic responsiveness and intracellular calcium handling abnormalities in Duchenne Muscular Dystrophy patients' induced pluripotent stem cell-derived cardiomyocytes.
Mekies LN, Regev D, Eisen B, Fernandez-Gracia J, Baskin P, Ben Jehuda R, Shulman R, Reiter I, Palty R, Arad M, Gottlieb E, Binah O. Mekies LN, et al. Among authors: arad m. J Cell Mol Med. 2021 Apr;25(8):3922-3934. doi: 10.1111/jcmm.16341. Epub 2021 Feb 22. J Cell Mol Med. 2021. PMID: 33619882 Free PMC article.
278 results