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Increased β2-adrenergic signaling promotes fracture healing through callus neovascularization in mice.
Jahn D, Knapstein PR, Otto E, Köhli P, Sevecke J, Graef F, Graffmann C, Fuchs M, Jiang S, Rickert M, Erdmann C, Appelt J, Revend L, Küttner Q, Witte J, Rahmani A, Duda G, Xie W, Donat A, Schinke T, Ivanov A, Tchouto MN, Beule D, Frosch KH, Baranowsky A, Tsitsilonis S, Keller J. Jahn D, et al. Among authors: appelt j. Sci Transl Med. 2024 Apr 17;16(743):eadk9129. doi: 10.1126/scitranslmed.adk9129. Epub 2024 Apr 17. Sci Transl Med. 2024. PMID: 38630849
Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization.
Jahn D, Knapstein PR, Otto E, Köhli P, Sevecke J, Graef F, Graffmann C, Fuchs M, Jiang S, Rickert M, Erdmann C, Appelt J, Revend L, Küttner Q, Witte J, Rahmani A, Duda G, Xie W, Donat A, Schinke T, Ivanov A, Tchouto MN, Beule D, Frosch KH, Baranowsky A, Tsitsilonis S, Keller J. Jahn D, et al. Among authors: appelt j. bioRxiv [Preprint]. 2023 Jul 16:2023.07.14.548550. doi: 10.1101/2023.07.14.548550. bioRxiv. 2023. PMID: 37502964 Free PMC article. Preprint.
Inactivation of the gene encoding procalcitonin prevents antibody-mediated arthritis.
Maleitzke T, Dietrich T, Hildebrandt A, Weber J, Appelt J, Jahn D, Otto E, Zocholl D, Jiang S, Baranowsky A, Duda GN, Tsitsilonis S, Keller J. Maleitzke T, et al. Among authors: appelt j. Inflamm Res. 2023 May;72(5):1069-1081. doi: 10.1007/s00011-023-01719-x. Epub 2023 Apr 11. Inflamm Res. 2023. PMID: 37039837
Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment.
Baranowsky A, Jahn D, Jiang S, Yorgan T, Ludewig P, Appelt J, Albrecht KK, Otto E, Knapstein P, Donat A, Winneberger J, Rosenthal L, Köhli P, Erdmann C, Fuchs M, Frosch KH, Tsitsilonis S, Amling M, Schinke T, Keller J. Baranowsky A, et al. Among authors: appelt j. Bone Res. 2022 Jan 27;10(1):9. doi: 10.1038/s41413-021-00172-y. Bone Res. 2022. PMID: 35087025 Free PMC article.
48 results