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Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.
Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170072. doi: 10.1098/rstb.2017.0072.
Philos Trans R Soc Lond B Biol Sci. 2018.
PMID: 29685976
Free PMC article.
Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay.
Aouadi W, Eydoux C, Coutard B, Martin B, Debart F, Vasseur JJ, Contreras JM, Morice C, Quérat G, Jung ML, Canard B, Guillemot JC, Decroly E.
Aouadi W, et al.
Antiviral Res. 2017 Aug;144:330-339. doi: 10.1016/j.antiviral.2017.06.021. Epub 2017 Jul 1.
Antiviral Res. 2017.
PMID: 28676301
Free PMC article.
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Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
Coutard B, Barral K, Lichière J, Selisko B, Martin B, Aouadi W, Lombardia MO, Debart F, Vasseur JJ, Guillemot JC, Canard B, Decroly E.
Coutard B, et al. Among authors: aouadi w.
J Virol. 2017 Feb 14;91(5):e02202-16. doi: 10.1128/JVI.02202-16. Print 2017 Mar 1.
J Virol. 2017.
PMID: 28031359
Free PMC article.
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Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.
Aouadi W, Blanjoie A, Vasseur JJ, Debart F, Canard B, Decroly E.
Aouadi W, et al.
J Virol. 2017 Feb 14;91(5):e02217-16. doi: 10.1128/JVI.02217-16. Print 2017 Mar 1.
J Virol. 2017.
PMID: 28031370
Free PMC article.
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Design, Synthesis and Discovery of N,N'-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication.
Spizzichino S, Mattedi G, Lauder K, Valle C, Aouadi W, Canard B, Decroly E, Kaptein SJF, Neyts J, Graham C, Sule Z, Barlow DJ, Silvestri R, Castagnolo D.
Spizzichino S, et al. Among authors: aouadi w.
ChemMedChem. 2020 Feb 17;15(4):385-390. doi: 10.1002/cmdc.201900533. Epub 2020 Jan 7.
ChemMedChem. 2020.
PMID: 31805205
Free PMC article.
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Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro.
Thames JE, Waters CD 3rd, Valle C, Bassetto M, Aouadi W, Martin B, Selisko B, Falat A, Coutard B, Brancale A, Canard B, Decroly E, Seley-Radtke KL.
Thames JE, et al. Among authors: aouadi w.
Bioorg Med Chem. 2020 Nov 15;28(22):115713. doi: 10.1016/j.bmc.2020.115713. Epub 2020 Aug 31.
Bioorg Med Chem. 2020.
PMID: 33128910
Free PMC article.
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Comparative analysis of rabies pathogenic and vaccine strains detection by RIG-I-like receptors.
Aouadi W, Najburg V, Legendre R, Varet H, Kergoat L, Tangy F, Larrous F, Komarova AV, Bourhy H.
Aouadi W, et al.
Microbes Infect. 2024 Mar 9:105321. doi: 10.1016/j.micinf.2024.105321. Online ahead of print.
Microbes Infect. 2024.
PMID: 38461968
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