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Design and synthesis of a fluorescent probe for Zn2+, 5,7-bis(N,N-dimethylaminosulfonyl)-8-hydroxyquinoline-pendant 1,4,7,10-tetraazacyclododecane and Zn2+-dependent hydrolytic and Zn2+-independent photochemical reactivation of its benzenesulfonyl-caged derivative.
Ohshima R, Kitamura M, Morita A, Shiro M, Yamada Y, Ikekita M, Kimura E, Aoki S. Ohshima R, et al. Among authors: aoki s. Inorg Chem. 2010 Feb 1;49(3):888-99. doi: 10.1021/ic901279t. Inorg Chem. 2010. PMID: 20039701
Sodium orthovanadate inhibits p53-mediated apoptosis.
Morita A, Yamamoto S, Wang B, Tanaka K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, Hosoi Y, Ikekita M. Morita A, et al. Among authors: aoki s. Cancer Res. 2010 Jan 1;70(1):257-65. doi: 10.1158/0008-5472.CAN-08-3771. Cancer Res. 2010. PMID: 20048077
Evaluation of zinc (II) chelators for inhibiting p53-mediated apoptosis.
Morita A, Ariyasu S, Ohya S, Takahashi I, Wang B, Tanaka K, Uchida T, Okazaki H, Hanaya K, Enomoto A, Nenoi M, Ikekita M, Aoki S, Hosoi Y. Morita A, et al. Among authors: aoki s. Oncotarget. 2013 Dec;4(12):2439-50. doi: 10.18632/oncotarget.1535. Oncotarget. 2013. PMID: 24280450 Free PMC article.
AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation.
Morita A, Ariyasu S, Wang B, Asanuma T, Onoda T, Sawa A, Tanaka K, Takahashi I, Togami S, Nenoi M, Inaba T, Aoki S. Morita A, et al. Among authors: aoki s. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1498-504. doi: 10.1016/j.bbrc.2014.07.037. Epub 2014 Jul 12. Biochem Biophys Res Commun. 2014. PMID: 25026551
Development of a novel sulfonate ester-based prodrug strategy.
Hanaya K, Yoshioka S, Ariyasu S, Aoki S, Shoji M, Sugai T. Hanaya K, et al. Among authors: aoki s. Bioorg Med Chem Lett. 2016 Jan 15;26(2):545-550. doi: 10.1016/j.bmcl.2015.11.074. Epub 2015 Nov 21. Bioorg Med Chem Lett. 2016. PMID: 26642767
A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist.
Morita A, Takahashi I, Sasatani M, Aoki S, Wang B, Ariyasu S, Tanaka K, Yamaguchi T, Sawa A, Nishi Y, Teraoka T, Ujita S, Kawate Y, Yanagawa C, Tanimoto K, Enomoto A, Nenoi M, Kamiya K, Nagata Y, Hosoi Y, Inaba T. Morita A, et al. Among authors: aoki s. Mol Cancer Ther. 2018 Feb;17(2):432-442. doi: 10.1158/1535-7163.MCT-16-0554. Epub 2017 Sep 22. Mol Cancer Ther. 2018. PMID: 28939557
2,790 results