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A mechanistic insight into 3,4-methylenedioxymethamphetamine ("ecstasy")-mediated hepatotoxicity.
Vet Q. 2011 Dec;31(4):193-205. doi: 10.1080/01652176.2011.642534. Epub 2011 Dec 13.
Vet Q. 2011.
PMID: 22151050
Review.
Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity.
Antolino-Lobo I, Meulenbelt J, Nijmeijer SM, Scherpenisse P, van den Berg M, van Duursen MB.
Antolino-Lobo I, et al.
Drug Metab Dispos. 2010 Jul;38(7):1105-12. doi: 10.1124/dmd.110.032359. Epub 2010 Apr 13.
Drug Metab Dispos. 2010.
PMID: 20388857
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3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition.
Antolino-Lobo I, Meulenbelt J, Nijmeijer SM, Maas-Bakker RF, Meijerman I, van den Berg M, van Duursen MB.
Antolino-Lobo I, et al.
Toxicol Lett. 2011 May 30;203(1):82-91. doi: 10.1016/j.toxlet.2011.03.007. Epub 2011 Mar 22.
Toxicol Lett. 2011.
PMID: 21402137
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Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants.
Antolino-Lobo I, Meulenbelt J, Molendijk J, Nijmeijer SM, Scherpenisse P, van den Berg M, van Duursen MB.
Antolino-Lobo I, et al.
Toxicology. 2011 Nov 18;289(2-3):175-84. doi: 10.1016/j.tox.2011.08.012. Epub 2011 Aug 17.
Toxicology. 2011.
PMID: 21871945
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