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FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4.
McClements L, Annett S, Yakkundi A, O'Rourke M, Valentine A, Moustafa N, Alqudah A, Simões BM, Furlong F, Short A, McIntosh SA, McCarthy HO, Clarke RB, Robson T. McClements L, et al. Among authors: annett s. BMC Cancer. 2019 Apr 11;19(1):351. doi: 10.1186/s12885-019-5500-0. BMC Cancer. 2019. PMID: 30975104 Free PMC article.
FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer.
Annett S, Moore G, Short A, Marshall A, McCrudden C, Yakkundi A, Das S, McCluggage WG, Nelson L, Harley I, Moustafa N, Kennedy CJ, deFazio A, Brand A, Sharma R, Brennan D, O'Toole S, O'Leary J, Bates M, O'Riain C, O'Connor D, Furlong F, McCarthy H, Kissenpfennig A, McClements L, Robson T. Annett S, et al. Br J Cancer. 2020 Feb;122(3):361-371. doi: 10.1038/s41416-019-0649-5. Epub 2019 Nov 27. Br J Cancer. 2020. PMID: 31772325 Free PMC article.
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.
Dowling JK, Afzal R, Gearing LJ, Cervantes-Silva MP, Annett S, Davis GM, De Santi C, Assmann N, Dettmer K, Gough DJ, Bantug GR, Hamid FI, Nally FK, Duffy CP, Gorman AL, Liddicoat AM, Lavelle EC, Hess C, Oefner PJ, Finlay DK, Davey GP, Robson T, Curtis AM, Hertzog PJ, Williams BRG, McCoy CE. Dowling JK, et al. Among authors: annett s. Nat Commun. 2021 Mar 5;12(1):1460. doi: 10.1038/s41467-021-21617-2. Nat Commun. 2021. PMID: 33674584 Free PMC article.
23 results