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Year Number of Results
2002 3
2003 4
2004 3
2005 3
2006 2
2007 2
2010 1
2011 1
2014 3
2015 2
2016 1
2017 5
2018 3
2019 2
2020 3
2021 1
2022 4
2023 4
2024 1

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Page 1
Oral USC-093, a novel homoserinamide analogue of the tyrosinamide (S)-HPMPA prodrug USC-087 has decreased nephrotoxicity while maintaining antiviral efficacy against human adenovirus infection of Syrian hamsters.
Tollefson AE, Riemann SB, Ying B, Spencer JF, Overhulse JM, Kashemirov BA, Wold WSM, McKenna CE, Toth K. Tollefson AE, et al. Antiviral Res. 2024 Feb;222:105799. doi: 10.1016/j.antiviral.2024.105799. Epub 2024 Jan 6. Antiviral Res. 2024. PMID: 38190973
Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability.
Gao S, Song L, Sylvester K, Mercorelli B, Loregian A, Toth K, Weiße RH, Useini A, Sträter N, Yang M, Ye B, Tollefson AE, Müller CE, Liu X, Zhan P. Gao S, et al. Among authors: tollefson ae. J Med Chem. 2023 Dec 14;66(23):16426-16440. doi: 10.1021/acs.jmedchem.3c01876. Epub 2023 Nov 22. J Med Chem. 2023. PMID: 37992202
NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin.
Lipka E, Chadderdon AM, Harteg CC, Doherty MK, Simon ES, Domagala JM, Reyna DM, Hutchings KM, Gan X, White AD, Hartline CB, Harden EA, Keith KA, Prichard MN, James SH, Cardin RD, Bernstein DI, Spencer JF, Tollefson AE, Wold WSM, Toth K. Lipka E, et al. Among authors: tollefson ae. Mol Pharm. 2023 Jan 2;20(1):370-382. doi: 10.1021/acs.molpharmaceut.2c00668. Epub 2022 Dec 9. Mol Pharm. 2023. PMID: 36484496 Free PMC article.
Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.
Gao S, Song L, Claff T, Woodson M, Sylvester K, Jing L, Weiße RH, Cheng Y, Sträter N, Schäkel L, Gütschow M, Ye B, Yang M, Zhang T, Kang D, Toth K, Tavis J, Tollefson AE, Müller CE, Zhan P, Liu X. Gao S, et al. Among authors: tollefson ae. J Med Chem. 2022 Dec 22;65(24):16902-16917. doi: 10.1021/acs.jmedchem.2c01716. Epub 2022 Dec 7. J Med Chem. 2022. PMID: 36475694
Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.
Gao S, Sylvester K, Song L, Claff T, Jing L, Woodson M, Weiße RH, Cheng Y, Schäkel L, Petry M, Gütschow M, Schiedel AC, Sträter N, Kang D, Xu S, Toth K, Tavis J, Tollefson AE, Müller CE, Liu X, Zhan P. Gao S, et al. Among authors: tollefson ae. J Med Chem. 2022 Oct 13;65(19):13343-13364. doi: 10.1021/acs.jmedchem.2c01146. Epub 2022 Sep 15. J Med Chem. 2022. PMID: 36107752
Biographical Feature: William S. M. Wold, Ph.D., 1944-2021.
Toth K, Tollefson AE, Chinnadurai G, Bellone CJ, Grandgenett DP, Morrison LA, Tavis JE. Toth K, et al. Among authors: tollefson ae. J Virol. 2021 Oct 27;95(22):e0118421. doi: 10.1128/JVI.01184-21. Epub 2021 Sep 22. J Virol. 2021. PMID: 34549981 Free PMC article. No abstract available.
Filociclovir Is a Potent In Vitro and In Vivo Inhibitor of Human Adenoviruses.
Toth K, Hussein ITM, Tollefson AE, Ying B, Spencer JF, Eagar J, James SH, Prichard MN, Wold WSM, Bowlin TL. Toth K, et al. Among authors: tollefson ae. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01299-20. doi: 10.1128/AAC.01299-20. Print 2020 Oct 20. Antimicrob Agents Chemother. 2020. PMID: 32816736 Free PMC article.
44 results