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Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy.
Chu CY, Lee YC, Hsieh CH, Yeh CT, Chao TY, Chen PH, Lin IH, Hsieh TH, Shih JW, Cheng CH, Chang CC, Lin PS, Huang YL, Chen TM, Yen Y, Ann DK, Kung HJ. Chu CY, et al. Among authors: ann dk. Theranostics. 2021 Jan 25;11(8):3624-3641. doi: 10.7150/thno.51795. eCollection 2021. Theranostics. 2021. PMID: 33664852 Free PMC article.
KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC.
Wang HJ, Pochampalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, Li CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ. Wang HJ, et al. Among authors: ann dk. Oncogene. 2019 Jan;38(1):17-32. doi: 10.1038/s41388-018-0414-x. Epub 2018 Aug 2. Oncogene. 2019. PMID: 30072740 Free PMC article.
Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction.
Cheng CT, Qi Y, Wang YC, Chi KK, Chung Y, Ouyang C, Chen YR, Oh ME, Sheng X, Tang Y, Liu YR, Lin HH, Kuo CY, Schones D, Vidal CM, Chu JC, Wang HJ, Chen YH, Miller KM, Chu P, Yen Y, Jiang L, Kung HJ, Ann DK. Cheng CT, et al. Among authors: ann dk. Commun Biol. 2018 Oct 26;1:178. doi: 10.1038/s42003-018-0178-4. eCollection 2018. Commun Biol. 2018. PMID: 30393775 Free PMC article.
Arginine Signaling and Cancer Metabolism.
Chen CL, Hsu SC, Ann DK, Yen Y, Kung HJ. Chen CL, et al. Among authors: ann dk. Cancers (Basel). 2021 Jul 15;13(14):3541. doi: 10.3390/cancers13143541. Cancers (Basel). 2021. PMID: 34298755 Free PMC article. Review.
178 results