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Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry.
Mazzon M, Ortega-Prieto AM, Imrie D, Luft C, Hess L, Czieso S, Grove J, Skelton JK, Farleigh L, Bugert JJ, Wright E, Temperton N, Angell R, Oxenford S, Jacobs M, Ketteler R, Dorner M, Marsh M. Mazzon M, et al. Among authors: angell r. Viruses. 2019 Feb 20;11(2):176. doi: 10.3390/v11020176. Viruses. 2019. PMID: 30791609 Free PMC article.
Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A.
Yu BYK, Tossounian MA, Hristov SD, Lawrence R, Arora P, Tsuchiya Y, Peak-Chew SY, Filonenko V, Oxenford S, Angell R, Gouge J, Skehel M, Gout I. Yu BYK, et al. Among authors: angell r. Redox Biol. 2021 Aug;44:101978. doi: 10.1016/j.redox.2021.101978. Epub 2021 Apr 15. Redox Biol. 2021. PMID: 33903070 Free PMC article.
Structure-activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling.
Ahmed AA, Chen S, Roman-Escorza M, Angell R, Oxenford S, McConville M, Barton N, Sunose M, Neidle D, Haider S, Arshad T, Neidle S. Ahmed AA, et al. Among authors: angell r. Sci Rep. 2024 Feb 11;14(1):3447. doi: 10.1038/s41598-024-54080-2. Sci Rep. 2024. PMID: 38342953 Free PMC article.
Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models.
Ahmed AA, Angell R, Oxenford S, Worthington J, Williams N, Barton N, Fowler TG, O'Flynn DE, Sunose M, McConville M, Vo T, Wilson WD, Karim SA, Morton JP, Neidle S. Ahmed AA, et al. Among authors: angell r. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. doi: 10.1021/acsmedchemlett.0c00317. eCollection 2020 Aug 13. ACS Med Chem Lett. 2020. PMID: 32832034 Free PMC article.
Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.
Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Cockerill GS, et al. Among authors: angell rm. J Med Chem. 2021 Apr 8;64(7):3658-3676. doi: 10.1021/acs.jmedchem.0c01882. Epub 2021 Mar 17. J Med Chem. 2021. PMID: 33729773
84 results