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A single dose of lipopolysaccharide into mice with emphysema mimics human chronic obstructive pulmonary disease exacerbation as assessed by micro-computed tomography.
Kobayashi S, Fujinawa R, Ota F, Kobayashi S, Angata T, Ueno M, Maeno T, Kitazume S, Yoshida K, Ishii T, Gao C, Ohtsubo K, Yamaguchi Y, Betsuyaku T, Kida K, Taniguchi N. Kobayashi S, et al. Among authors: angata t. Am J Respir Cell Mol Biol. 2013 Dec;49(6):971-7. doi: 10.1165/rcmb.2013-0074OC. Am J Respir Cell Mol Biol. 2013. PMID: 23822858
α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).
Kamio K, Yoshida T, Gao C, Ishii T, Ota F, Motegi T, Kobayashi S, Fujinawa R, Ohtsubo K, Kitazume S, Angata T, Azuma A, Gemma A, Nishimura M, Betsuyaku T, Kida K, Taniguchi N. Kamio K, et al. Among authors: angata t. Biochem Biophys Res Commun. 2012 Jul 20;424(1):112-7. doi: 10.1016/j.bbrc.2012.06.081. Epub 2012 Jun 23. Biochem Biophys Res Commun. 2012. PMID: 22732410
High affinity sugar ligands of C-type lectin receptor langerin.
Ota F, Hirayama T, Kizuka Y, Yamaguchi Y, Fujinawa R, Nagata M, Ismanto HS, Lepenies B, Aretz J, Rademacher C, Seeberger PH, Angata T, Kitazume S, Yoshida K, Betsuyaku T, Kida K, Yamasaki S, Taniguchi N. Ota F, et al. Among authors: angata t. Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1592-1601. doi: 10.1016/j.bbagen.2018.04.004. Epub 2018 Apr 7. Biochim Biophys Acta Gen Subj. 2018. PMID: 29631057
Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.
Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Soto PC, Chang YC, Secundino I, Gao CX, Ohtsubo K, Kitazume S, Nizet V, Varki A, Gemma A, Kida K, Taniguchi N. Angata T, et al. Cell Mol Life Sci. 2013 Sep;70(17):3199-210. doi: 10.1007/s00018-013-1311-7. Epub 2013 Mar 22. Cell Mol Life Sci. 2013. PMID: 23519826 Free PMC article.
Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle.
Shirato K, Nakajima K, Korekane H, Takamatsu S, Gao C, Angata T, Ohtsubo K, Taniguchi N. Shirato K, et al. Among authors: angata t. J Clin Biochem Nutr. 2011 Jan;48(1):20-5. doi: 10.3164/jcbn.11-015FR. Epub 2010 Dec 29. J Clin Biochem Nutr. 2011. PMID: 21297907 Free PMC article.
Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells.
Shirato K, Gao C, Ota F, Angata T, Shogomori H, Ohtsubo K, Yoshida K, Lepenies B, Taniguchi N. Shirato K, et al. Among authors: angata t. Biochem Biophys Res Commun. 2013 Jun 7;435(3):460-5. doi: 10.1016/j.bbrc.2013.05.009. Epub 2013 May 14. Biochem Biophys Res Commun. 2013. PMID: 23680662
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