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Page 1
Alzheimer and Parkinson diseases, frontotemporal lobar degeneration and amyotrophic lateral sclerosis overlapping neuropathology start in the first two decades of life in pollution exposed urbanites and brain ultrafine particulate matter and industrial nanoparticles, including Fe, Ti, Al, V, Ni, Hg, Co, Cu, Zn, Ag, Pt, Ce, La, Pr and W are key players. Metropolitan Mexico City health crisis is in progress.
Calderón-Garcidueñas L, Stommel EW, Torres-Jardón R, Hernández-Luna J, Aiello-Mora M, González-Maciel A, Reynoso-Robles R, Pérez-Guillé B, Silva-Pereyra HG, Tehuacanero-Cuapa S, Rodríguez-Gómez A, Lachmann I, Galaz-Montoya C, Doty RL, Roy A, Mukherjee PS. Calderón-Garcidueñas L, et al. Among authors: gonzalez maciel a. Front Hum Neurosci. 2024 Jan 12;17:1297467. doi: 10.3389/fnhum.2023.1297467. eCollection 2023. Front Hum Neurosci. 2024. PMID: 38283093 Free PMC article.
Sleep matters: Neurodegeneration spectrum heterogeneity, combustion and friction ultrafine particles, industrial nanoparticle pollution, and sleep disorders-Denial is not an option.
Calderón-Garcidueñas L, Torres-Jardón R, Greenough GP, Kulesza R, González-Maciel A, Reynoso-Robles R, García-Alonso G, Chávez-Franco DA, García-Rojas E, Brito-Aguilar R, Silva-Pereyra HG, Ayala A, Stommel EW, Mukherjee PS. Calderón-Garcidueñas L, et al. Among authors: gonzalez maciel a. Front Neurol. 2023 Feb 27;14:1117695. doi: 10.3389/fneur.2023.1117695. eCollection 2023. Front Neurol. 2023. PMID: 36923490 Free PMC article. Review.
TDP-43 CSF Concentrations Increase Exponentially with Age in Metropolitan Mexico City Young Urbanites Highly Exposed to PM2.5 and Ultrafine Particles and Historically Showing Alzheimer and Parkinson's Hallmarks. Brain TDP-43 Pathology in MMC Residents Is Associated with High Cisternal CSF TDP-43 Concentrations.
Calderón-Garcidueñas L, Stommel EW, Lachmann I, Waniek K, Chao CK, González-Maciel A, García-Rojas E, Torres-Jardón R, Delgado-Chávez R, Mukherjee PS. Calderón-Garcidueñas L, et al. Among authors: gonzalez maciel a. Toxics. 2022 Sep 24;10(10):559. doi: 10.3390/toxics10100559. Toxics. 2022. PMID: 36287840 Free PMC article.
Environmentally Toxic Solid Nanoparticles in Noradrenergic and Dopaminergic Nuclei and Cerebellum of Metropolitan Mexico City Children and Young Adults with Neural Quadruple Misfolded Protein Pathologies and High Exposures to Nano Particulate Matter.
Calderón-Garcidueñas L, González-Maciel A, Reynoso-Robles R, Silva-Pereyra HG, Torres-Jardón R, Brito-Aguilar R, Ayala A, Stommel EW, Delgado-Chávez R. Calderón-Garcidueñas L, et al. Among authors: gonzalez maciel a. Toxics. 2022 Mar 29;10(4):164. doi: 10.3390/toxics10040164. Toxics. 2022. PMID: 35448425 Free PMC article.
Potential Neuroprotective Effect of Cannabinoids in COVID-19 Patients.
Cortes-Altamirano JL, Yáñez-Pizaña A, Reyes-Long S, Angélica GM, Bandala C, Bonilla-Jaime H, Alfaro-Rodríguez A. Cortes-Altamirano JL, et al. Among authors: angelica gm. Curr Top Med Chem. 2022;22(16):1326-1345. doi: 10.2174/1568026622666220405143003. Curr Top Med Chem. 2022. PMID: 35382723 Review.
Environmental Nanoparticles Reach Human Fetal Brains.
Calderón-Garcidueñas L, Pérez-Calatayud ÁA, González-Maciel A, Reynoso-Robles R, Silva-Pereyra HG, Ramos-Morales A, Torres-Jardón R, Soberanes-Cerino CJ, Carrillo-Esper R, Briones-Garduño JC, Conde-Gutiérrez YDS. Calderón-Garcidueñas L, et al. Among authors: gonzalez maciel a. Biomedicines. 2022 Feb 9;10(2):410. doi: 10.3390/biomedicines10020410. Biomedicines. 2022. PMID: 35203619 Free PMC article.
Environmental Fe, Ti, Al, Cu, Hg, Bi, and Si Nanoparticles in the Atrioventricular Conduction Axis and the Associated Ultrastructural Damage in Young Urbanites: Cardiac Arrhythmias Caused by Anthropogenic, Industrial, E-Waste, and Indoor Nanoparticles.
Calderón-Garcidueñas L, González-Maciel A, Reynoso-Robles R, Rodríguez-López JL, Silva-Pereyra HG, Labrada-Delgado GJ, Pérez-Guillé B, Soriano-Rosales RE, Jiménez-Bravo Luna MA, Brito-Aguilar R, Mukherjee PS, Gayosso-Chávez C, Delgado-Chávez R. Calderón-Garcidueñas L, et al. Among authors: gonzalez maciel a. Environ Sci Technol. 2021 Jun 15;55(12):8203-8214. doi: 10.1021/acs.est.1c01733. Epub 2021 Jun 3. Environ Sci Technol. 2021. PMID: 34081443
Environmental Nanoparticles, SARS-CoV-2 Brain Involvement, and Potential Acceleration of Alzheimer's and Parkinson's Diseases in Young Urbanites Exposed to Air Pollution.
Calderón-Garcidueñas L, Torres-Jardón R, Franco-Lira M, Kulesza R, González-Maciel A, Reynoso-Robles R, Brito-Aguilar R, García-Arreola B, Revueltas-Ficachi P, Barrera-Velázquez JA, García-Alonso G, García-Rojas E, Mukherjee PS, Delgado-Chávez R. Calderón-Garcidueñas L, et al. Among authors: gonzalez maciel a. J Alzheimers Dis. 2020;78(2):479-503. doi: 10.3233/JAD-200891. J Alzheimers Dis. 2020. PMID: 32955466 Review.
Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portal.
Calderón-Garcidueñas L, González-Maciel A, Reynoso-Robles R, Hammond J, Kulesza R, Lachmann I, Torres-Jardón R, Mukherjee PS, Maher BA. Calderón-Garcidueñas L, et al. Among authors: gonzalez maciel a. Environ Res. 2020 Dec;191:110139. doi: 10.1016/j.envres.2020.110139. Epub 2020 Sep 2. Environ Res. 2020. PMID: 32888951
Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution.
Calderón-Garcidueñas L, Herrera-Soto A, Jury N, Maher BA, González-Maciel A, Reynoso-Robles R, Ruiz-Rudolph P, van Zundert B, Varela-Nallar L. Calderón-Garcidueñas L, et al. Among authors: gonzalez maciel a. Environ Res. 2020 Apr;183:109226. doi: 10.1016/j.envres.2020.109226. Epub 2020 Feb 4. Environ Res. 2020. PMID: 32045727
52 results