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3,3',5,5'-Tetramethoxybiphenyl-4,4'diol triggers oxidative stress, metabolic changes, and apoptosis-like process by reducing the PI3K/AKT/NF-κB pathway in the NCI-H460 lung cancer cell line.
Concato-Lopes VM, Silva TF, Detoni MB, Cruz EMS, Gonçalves MD, da Silva Bortoleti BT, Tomiotto-Pellissier F, Carloto ACM, Madureira MB, Rodrigues ACJ, Schirmann JG, Barbosa-Dekker AM, Dekker RFH, Conchon-Costa I, Panis C, Lazarin-Bidóia D, Miranda-Sapla MM, Mantovani MS, Pavanelli WR. Concato-Lopes VM, et al. Among authors: barbosa dekker am. Biomed Pharmacother. 2024 Jan;170:115979. doi: 10.1016/j.biopha.2023.115979. Epub 2023 Dec 6. Biomed Pharmacother. 2024. PMID: 38061138 Free article.
In-vitro biological evaluation of 3,3',5,5'-tetramethoxy-biphenyl-4,4'-diol and molecular docking studies on trypanothione reductase and Gp63 from Leishmania amazonensis demonstrated anti-leishmania potential.
Schirmann JG, Bortoleti BTS, Gonçalves MD, Tomiotto-Pellissier F, Camargo PG, Miranda-Sapla MM, Lima CHS, Bispo MLF, Costa IN, Conchon-Costa I, Pavanelli WR, Dekker RFH, Barbosa-Dekker AM. Schirmann JG, et al. Among authors: barbosa dekker am. Sci Rep. 2023 Apr 28;13(1):6928. doi: 10.1038/s41598-023-34124-9. Sci Rep. 2023. PMID: 37117253 Free PMC article.
Sulfonated (1 → 6)-β-d-Glucan (Lasiodiplodan): A Promising Candidate against the Acyclovir-Resistant Herpes Simplex Virus Type 1 (HSV-1) Strain.
Wouk J, Celestino GG, Rodrigues BCD, Malfatti CRM, Cunha MAA, Orsato A, Barbosa-Dekker AM, Dekker RFH, Lonni AASG, Reis Tavares E, Faccin-Galhardi LC. Wouk J, et al. Among authors: barbosa dekker am. Biomacromolecules. 2022 Oct 10;23(10):4041-4052. doi: 10.1021/acs.biomac.2c00156. Epub 2022 Sep 29. Biomacromolecules. 2022. PMID: 36173245
Oral administration of botryosphaeran [(1 → 3)(1 → 6)-β-d-glucan] reduces inflammation through modulation of leukocytes and has limited effect on inflammatory nociception.
Silva NA, Pereira BG, Santos JA, Guarnier FA, Barbosa-Dekker AM, Dekker RFH, Kassuya CAL, Bernardes SS. Silva NA, et al. Among authors: barbosa dekker am. Cell Biochem Funct. 2022 Aug;40(6):578-588. doi: 10.1002/cbf.3727. Epub 2022 Jul 5. Cell Biochem Funct. 2022. PMID: 35788958
Anticancer effects of carboxymethylated (1→3)(1→6)-β-D-glucan (botryosphaeran) on multicellular tumor spheroids of MCF-7 cells as a model of breast cancer.
Fujiike AY, Lee CYAL, Rodrigues FST, Oliveira LCB, Barbosa-Dekker AM, Dekker RFH, Cólus IMS, Serpeloni JM. Fujiike AY, et al. Among authors: barbosa dekker am. J Toxicol Environ Health A. 2022 Jul 3;85(13):521-537. doi: 10.1080/15287394.2022.2048153. Epub 2022 Mar 7. J Toxicol Environ Health A. 2022. PMID: 35255775
Electrochemical Characterization of the Laccase-Catalyzed Oxidation of 2,6-Dimethoxyphenol: an Insight into the Direct Electron Transfer by Enzyme and Enzyme-Mediator System.
Mattos GJ, Schirmann JG, Salamanca-Neto CAR, Dekker RFH, Barbosa-Dekker AM, Sartori ER. Mattos GJ, et al. Among authors: barbosa dekker am. Appl Biochem Biotechnol. 2022 Oct;194(10):4348-4361. doi: 10.1007/s12010-022-03838-3. Epub 2022 Feb 11. Appl Biochem Biotechnol. 2022. PMID: 35146637
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules.
Carloto ACM, Bortoleti BTDS, Rodrigues ACJ, Silva TF, Tomiotto-Pellissier F, Bidóia DL, Gonçalves MD, Assolini JP, Dekker RFH, Barbosa-Dekker AM, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Pavanelli WR. Carloto ACM, et al. Among authors: barbosa dekker am. Chem Biol Interact. 2022 Jan 5;351:109713. doi: 10.1016/j.cbi.2021.109713. Epub 2021 Oct 23. Chem Biol Interact. 2022. PMID: 34699765
35 results