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Designed Spiroketal Protein Modulation.
Scheepstra M, Andrei SA, Unver MY, Hirsch AKH, Leysen S, Ottmann C, Brunsveld L, Milroy LG. Scheepstra M, et al. Among authors: andrei sa. Angew Chem Int Ed Engl. 2017 May 8;56(20):5480-5484. doi: 10.1002/anie.201612504. Epub 2017 Apr 13. Angew Chem Int Ed Engl. 2017. PMID: 28407400 Free PMC article.
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.
Ritzefeld M, Zhang L, Xiao Z, Andrei SA, Boyd O, Masumoto N, Rodgers UR, Artelsmair M, Sefer L, Hayes A, Gavriil ES, Raynaud FI, Burke R, Blagg J, Rzepa HS, Siebold C, Magee AI, Lanyon-Hogg T, Tate EW. Ritzefeld M, et al. Among authors: andrei sa. J Med Chem. 2024 Jan 25;67(2):1061-1078. doi: 10.1021/acs.jmedchem.3c01363. Epub 2024 Jan 10. J Med Chem. 2024. PMID: 38198226 Free PMC article.
Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
Doveston RG, Kuusk A, Andrei SA, Leysen S, Cao Q, Castaldi MP, Hendricks A, Brunsveld L, Chen H, Boyd H, Ottmann C. Doveston RG, et al. Among authors: andrei sa. FEBS Lett. 2017 Aug;591(16):2449-2457. doi: 10.1002/1873-3468.12723. Epub 2017 Aug 6. FEBS Lett. 2017. PMID: 28640363 Free article.
Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
Scheepstra M, Andrei SA, de Vries RMJM, Meijer FA, Ma JN, Burstein ES, Olsson R, Ottmann C, Milroy LG, Brunsveld L. Scheepstra M, et al. Among authors: andrei sa. ACS Chem Neurosci. 2017 Sep 20;8(9):2065-2077. doi: 10.1021/acschemneuro.7b00216. Epub 2017 Jul 24. ACS Chem Neurosci. 2017. PMID: 28691794 Free PMC article.
Stabilization of protein-protein interactions in drug discovery.
Andrei SA, Sijbesma E, Hann M, Davis J, O'Mahony G, Perry MWD, Karawajczyk A, Eickhoff J, Brunsveld L, Doveston RG, Milroy LG, Ottmann C. Andrei SA, et al. Expert Opin Drug Discov. 2017 Sep;12(9):925-940. doi: 10.1080/17460441.2017.1346608. Epub 2017 Jul 11. Expert Opin Drug Discov. 2017. PMID: 28695752 Review.
20 results