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Year Number of Results
2009 1
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2011 3
2012 2
2013 1
2014 4
2015 3
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2019 6
2020 9
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2022 4
2023 4
2024 4

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Page 1
Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure.
Ebmeyer J, Najjar A, Lange D, Boettcher M, Voß S, Brandmair K, Meinhardt J, Kuehnl J, Hewitt NJ, Krueger CT, Schepky A. Ebmeyer J, et al. Among authors: schepky a. Front Pharmacol. 2024 Mar 7;15:1345992. doi: 10.3389/fphar.2024.1345992. eCollection 2024. Front Pharmacol. 2024. PMID: 38515841 Free PMC article.
Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin.
Falckenhayn C, Bienkowska A, Söhle J, Wegner K, Raddatz G, Kristof B, Kuck D, Siegner R, Kaufmann R, Korn J, Baumann S, Lange D, Schepky A, Völzke H, Kaderali L, Winnefeld M, Lyko F, Grönniger E. Falckenhayn C, et al. Among authors: schepky a. Front Aging. 2024 Mar 4;4:1258184. doi: 10.3389/fragi.2023.1258184. eCollection 2023. Front Aging. 2024. PMID: 38500495 Free PMC article.
Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene.
Brandmair K, Tao TP, Gerlach S, Przibilla J, Schepky A, Marx U, Hewitt NJ, Kühnl J, Maschmeyer I. Brandmair K, et al. Among authors: schepky a. J Appl Toxicol. 2024 Mar;44(3):333-343. doi: 10.1002/jat.4542. Epub 2023 Sep 12. J Appl Toxicol. 2024. PMID: 37699698 Free article.
Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions.
Tao TP, Maschmeyer I, LeCluyse EL, Rogers E, Brandmair K, Gerlach S, Przibilla J, Kern F, Genies C, Jacques C, Najjar A, Schepky A, Marx U, Kühnl J, Hewitt NJ. Tao TP, et al. Among authors: schepky a. Front Pharmacol. 2023 Feb 8;14:1076254. doi: 10.3389/fphar.2023.1076254. eCollection 2023. Front Pharmacol. 2023. PMID: 36843954 Free PMC article.
Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment - A case study with parabens.
Ouedraogo G, Alexander-White C, Bury D, Clewell HJ 3rd, Cronin M, Cull T, Dent M, Desprez B, Detroyer A, Ellison C, Giammanco S, Hack E, Hewitt NJ, Kenna G, Klaric M, Kreiling R, Lester C, Mahony C, Mombelli E, Naciff J, O'Brien J, Schepky A, Tozer S, van der Burg B, van Vugt-Lussenburg B, Stuard S, Cosmetics Europe. Ouedraogo G, et al. Among authors: schepky a. Regul Toxicol Pharmacol. 2022 Jul;132:105161. doi: 10.1016/j.yrtph.2022.105161. Epub 2022 May 1. Regul Toxicol Pharmacol. 2022. PMID: 35508214 Free article.
Use of in vitro metabolism and biokinetics assays to refine predicted in vivo and in vitro internal exposure to the cosmetic ingredient, phenoxyethanol, for use in risk assessment.
Hewitt NJ, Troutman J, Przibilla J, Schepky A, Ouédraogo G, Mahony C, Kenna G, Varçin M, Dent MP; Cosmetics Europe. Electronic address: cosmeticseurope@cosmeticseurope.eu. Hewitt NJ, et al. Among authors: schepky a. Regul Toxicol Pharmacol. 2022 Jun;131:105132. doi: 10.1016/j.yrtph.2022.105132. Epub 2022 Feb 22. Regul Toxicol Pharmacol. 2022. PMID: 35217105 Free article.
Use of Physiologically-Based Kinetics Modelling to Reliably Predict Internal Concentrations of the UV Filter, Homosalate, After Repeated Oral and Topical Application.
Najjar A, Schepky A, Krueger CT, Dent M, Cable S, Li H, Grégoire S, Roussel L, Noel-Voisin A, Hewitt NJ, Cardamone E. Najjar A, et al. Among authors: schepky a. Front Pharmacol. 2022 Jan 4;12:802514. doi: 10.3389/fphar.2021.802514. eCollection 2021. Front Pharmacol. 2022. PMID: 35058784 Free PMC article.
A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment.
Alexander-White C, Bury D, Cronin M, Dent M, Hack E, Hewitt NJ, Kenna G, Naciff J, Ouedraogo G, Schepky A, Mahony C, Europe C. Alexander-White C, et al. Among authors: schepky a. Regul Toxicol Pharmacol. 2022 Mar;129:105094. doi: 10.1016/j.yrtph.2021.105094. Epub 2022 Jan 4. Regul Toxicol Pharmacol. 2022. PMID: 34990780 Free article.
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients - A case study on caffeine.
Bury D, Alexander-White C, Clewell HJ 3rd, Cronin M, Desprez B, Detroyer A, Efremenko A, Firman J, Hack E, Hewitt NJ, Kenna G, Klaric M, Lester C, Mahony C, Ouedraogo G, Paini A, Schepky A; Cosmetics Europe. Bury D, et al. Among authors: schepky a. Regul Toxicol Pharmacol. 2021 Jul;123:104931. doi: 10.1016/j.yrtph.2021.104931. Epub 2021 Apr 24. Regul Toxicol Pharmacol. 2021. PMID: 33905778 Free article.
42 results