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Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Rodrigues TS, de Sá KSG, Ishimoto AY, Becerra A, Oliveira S, Almeida L, Gonçalves AV, Perucello DB, Andrade WA, Castro R, Veras FP, Toller-Kawahisa JE, Nascimento DC, de Lima MHF, Silva CMS, Caetite DB, Martins RB, Castro IA, Pontelli MC, de Barros FC, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Santana RC, Vilar FC, Auxiliadora-Martins M, Luppino-Assad R, de Almeida SCL, de Oliveira FR, Batah SS, Siyuan L, Benatti MN, Cunha TM, Alves-Filho JC, Cunha FQ, Cunha LD, Frantz FG, Kohlsdorf T, Fabro AT, Arruda E, de Oliveira RDR, Louzada-Junior P, Zamboni DS. Rodrigues TS, et al. Among authors: andrade wa. J Exp Med. 2021 Mar 1;218(3):e20201707. doi: 10.1084/jem.20201707. J Exp Med. 2021. PMID: 33231615 Free PMC article.
Apoptosis-associated speck-like protein containing a caspase recruitment domain inflammasomes mediate IL-1β response and host resistance to Trypanosoma cruzi infection.
Silva GK, Costa RS, Silveira TN, Caetano BC, Horta CV, Gutierrez FR, Guedes PM, Andrade WA, De Niz M, Gazzinelli RT, Zamboni DS, Silva JS. Silva GK, et al. Among authors: andrade wa. J Immunol. 2013 Sep 15;191(6):3373-83. doi: 10.4049/jimmunol.1203293. Epub 2013 Aug 21. J Immunol. 2013. PMID: 23966627
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Ataide MA, Andrade WA, Zamboni DS, Wang D, Souza Mdo C, Franklin BS, Elian S, Martins FS, Pereira D, Reed G, Fitzgerald KA, Golenbock DT, Gazzinelli RT. Ataide MA, et al. Among authors: andrade wa. PLoS Pathog. 2014 Jan;10(1):e1003885. doi: 10.1371/journal.ppat.1003885. Epub 2014 Jan 16. PLoS Pathog. 2014. PMID: 24453977 Free PMC article. Clinical Trial.
Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis.
Souza MC, Fonseca DM, Kanashiro A, Benevides L, Medina TS, Dias MS, Andrade WA, Bonfá G, Silva MAB, Gozzi A, Borges MC, Gazzinelli RT, Alves-Filho JC, Cunha FQ, Silva JS. Souza MC, et al. Among authors: andrade wa. Front Cell Infect Microbiol. 2017 Apr 7;7:116. doi: 10.3389/fcimb.2017.00116. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28439500 Free PMC article.
NLRC4 biology in immunity and inflammation.
Andrade WA, Zamboni DS. Andrade WA, et al. J Leukoc Biol. 2020 Oct;108(4):1117-1127. doi: 10.1002/JLB.3MR0420-573R. Epub 2020 Jun 12. J Leukoc Biol. 2020. PMID: 32531834 Review.
Lipid droplet accumulation occurs early following Salmonella infection and contributes to intracellular bacterial survival and replication.
Kiarely Souza E, Pereira-Dutra FS, Rajão MA, Ferraro-Moreira F, Goltara-Gomes TC, Cunha-Fernandes T, Santos JDC, Prestes EB, Andrade WA, Zamboni DS, Bozza MT, Bozza PT. Kiarely Souza E, et al. Among authors: andrade wa. Mol Microbiol. 2022 Feb;117(2):293-306. doi: 10.1111/mmi.14844. Epub 2021 Dec 1. Mol Microbiol. 2022. PMID: 34783412 Free article.
Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection.
de Almeida L, da Silva ALN, Rodrigues TS, Oliveira S, Ishimoto AY, Seribelli AA, Becerra A, Andrade WA, Ataide MA, Caetano CCS, de Sá KSG, Pelisson N, Martins RB, de Paula Souza J, Arruda E, Batah SS, Castro R, Frantz FG, Cunha FQ, Cunha TM, Fabro AT, Cunha LD, Louzada-Junior P, de Oliveira RDR, Zamboni DS. de Almeida L, et al. Among authors: andrade wa. Sci Adv. 2022 Sep 16;8(37):eabo5400. doi: 10.1126/sciadv.abo5400. Epub 2022 Sep 14. Sci Adv. 2022. PMID: 36103544 Free PMC article.
31 results