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2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.
Mezeiova E, Janockova J, Andrys R, Soukup O, Kobrlova T, Muckova L, Pejchal J, Simunkova M, Handl J, Micankova P, Capek J, Rousar T, Hrabinova M, Nepovimova E, Marco-Contelles JL, Valko M, Korabecny J. Mezeiova E, et al. Among authors: andrys r. Eur J Med Chem. 2021 Feb 5;211:113112. doi: 10.1016/j.ejmech.2020.113112. Epub 2020 Dec 18. Eur J Med Chem. 2021. PMID: 33360800
Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies.
Mamun AA, Pidaný F, Hulcová D, Maříková J, Kučera T, Schmidt M, Catapano MC, Hrabinová M, Jun D, Múčková L, Kuneš J, Janoušek J, Andrýs R, Nováková L, Peřinová R, Maafi N, Soukup O, Korábečný J, Cahlíková L. Mamun AA, et al. Among authors: andrys r. Int J Mol Sci. 2021 Aug 2;22(15):8308. doi: 10.3390/ijms22158308. Int J Mol Sci. 2021. PMID: 34361074 Free PMC article.
Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities.
Chrienova Z, Nepovimova E, Andrys R, Dolezal R, Janockova J, Muckova L, Fabova L, Soukup O, Oleksak P, Valis M, Korabecny J, Marco-Contelles J, Kuca K. Chrienova Z, et al. Among authors: andrys r. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2605-2620. doi: 10.1080/14756366.2022.2122054. J Enzyme Inhib Med Chem. 2022. PMID: 36131624 Free PMC article.
Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease.
Svobodova B, Pulkrabkova L, Panek D, Misiachna A, Kolcheva M, Andrys R, Handl J, Capek J, Nyvltova P, Rousar T, Prchal L, Hepnarova V, Hrabinova M, Muckova L, Tosnerova D, Karabanovich G, Finger V, Soukup O, Horak M, Korabecny J. Svobodova B, et al. Among authors: andrys r. Int J Mol Sci. 2023 May 23;24(11):9124. doi: 10.3390/ijms24119124. Int J Mol Sci. 2023. PMID: 37298087 Free PMC article.
41 results