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Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components.
Boyles MS, Kristl T, Andosch A, Zimmermann M, Tran N, Casals E, Himly M, Puntes V, Huber CG, Lütz-Meindl U, Duschl A. Boyles MS, et al. Among authors: andosch a. J Nanobiotechnology. 2015 Nov 18;13:84. doi: 10.1186/s12951-015-0146-9. J Nanobiotechnology. 2015. PMID: 26582370 Free PMC article.
Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation.
Li Y, Shi Z, Radauer-Preiml I, Andosch A, Casals E, Luetz-Meindl U, Cobaleda M, Lin Z, Jaberi-Douraki M, Italiani P, Horejs-Hoeck J, Himly M, Monteiro-Riviere NA, Duschl A, Puntes VF, Boraschi D. Li Y, et al. Among authors: andosch a. Nanotoxicology. 2017 Nov-Dec;11(9-10):1157-1175. doi: 10.1080/17435390.2017.1401142. Epub 2017 Dec 1. Nanotoxicology. 2017. PMID: 29192556
Gold nanoparticles (AuNPs) impair LPS-driven immune responses by promoting a tolerogenic-like dendritic cell phenotype with altered endosomal structures.
Michelini S, Barbero F, Prinelli A, Steiner P, Weiss R, Verwanger T, Andosch A, Lütz-Meindl U, Puntes VF, Drobne D, Duschl A, Horejs-Hoeck J. Michelini S, et al. Among authors: andosch a. Nanoscale. 2021 Apr 30;13(16):7648-7666. doi: 10.1039/d0nr09153g. Nanoscale. 2021. PMID: 33928963 Free PMC article.
20 results