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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
Lamarre D, Anderson PC, Bailey M, Beaulieu P, Bolger G, Bonneau P, Bös M, Cameron DR, Cartier M, Cordingley MG, Faucher AM, Goudreau N, Kawai SH, Kukolj G, Lagacé L, LaPlante SR, Narjes H, Poupart MA, Rancourt J, Sentjens RE, St George R, Simoneau B, Steinmann G, Thibeault D, Tsantrizos YS, Weldon SM, Yong CL, Llinàs-Brunet M. Lamarre D, et al. Among authors: anderson pc. Nature. 2003 Nov 13;426(6963):186-9. doi: 10.1038/nature02099. Epub 2003 Oct 26. Nature. 2003. PMID: 14578911 Free article. Clinical Trial.
Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection.
Beaulieu PL, Anderson PC, Bethell R, Bös M, Bousquet Y, Brochu C, Cordingley MG, Fazal G, Garneau M, Gillard JR, Kawai S, Marquis M, McKercher G, Poupart MA, Stammers T, Thavonekham B, Wernic D, Duan J, Kukolj G. Beaulieu PL, et al. Among authors: anderson pc. J Med Chem. 2014 Dec 11;57(23):10130-43. doi: 10.1021/jm501532z. Epub 2014 Nov 25. J Med Chem. 2014. PMID: 25393851
Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.
Beaulieu PL, Wernic D, Abraham A, Anderson PC, Bogri T, Bousquet Y, Croteau G, Guse I, Lamarre D, Liard F, Paris W, Thibeault D, Pav S, Tong L. Beaulieu PL, et al. Among authors: anderson pc. J Med Chem. 1997 Jul 4;40(14):2164-76. doi: 10.1021/jm9606608. J Med Chem. 1997. PMID: 9216835
Discovery of non-peptidic P2-P3 butanediamide renin inhibitors with high oral efficacy.
Simoneau B, Lavallée P, Anderson PC, Bailey M, Bantle G, Berthiaume S, Chabot C, Fazal G, Halmos T, Ogilvie WW, Poupart MA, Thavonekham B, Xin Z, Thibeault D, Bolger G, Panzenbeck M, Winquist R, Jung GL. Simoneau B, et al. Among authors: anderson pc. Bioorg Med Chem. 1999 Mar;7(3):489-508. doi: 10.1016/s0968-0896(98)00265-x. Bioorg Med Chem. 1999. PMID: 10220035
169 results