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A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency.
Andersen OM, Bøgh N, Landau AM, Pløen GG, Jensen AMG, Monti G, Ulhøi BP, Nyengaard JR, Jacobsen KR, Jørgensen MM, Holm IE, Kristensen ML, Alstrup AKO, Hansen ESS, Teunissen CE, Breidenbach L, Droescher M, Liu Y, Pedersen HS, Callesen H, Luo Y, Bolund L, Brooks DJ, Laustsen C, Small SA, Mikkelsen LF, Sørensen CB. Andersen OM, et al. Cell Rep Med. 2022 Sep 20;3(9):100740. doi: 10.1016/j.xcrm.2022.100740. Epub 2022 Sep 12. Cell Rep Med. 2022. PMID: 36099918 Free PMC article.
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P. Rogaeva E, et al. Among authors: andersen om. Nat Genet. 2007 Feb;39(2):168-77. doi: 10.1038/ng1943. Epub 2007 Jan 14. Nat Genet. 2007. PMID: 17220890 Free PMC article.
Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing.
Fjorback AW, Seaman M, Gustafsen C, Mehmedbasic A, Gokool S, Wu C, Militz D, Schmidt V, Madsen P, Nyengaard JR, Willnow TE, Christensen EI, Mobley WB, Nykjær A, Andersen OM. Fjorback AW, et al. Among authors: andersen om. J Neurosci. 2012 Jan 25;32(4):1467-80. doi: 10.1523/JNEUROSCI.2272-11.2012. J Neurosci. 2012. PMID: 22279231 Free PMC article.
An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor.
Blechingberg J, Poulsen ASA, Kjølby M, Monti G, Allen M, Ivarsen AK, Lincoln SJ, Thotakura G, Vægter CB, Ertekin-Taner N, Nykjær A, Andersen OM. Blechingberg J, et al. Among authors: andersen om. Neurobiol Aging. 2018 Nov;71:266.e11-266.e24. doi: 10.1016/j.neurobiolaging.2018.06.021. Epub 2018 Jun 28. Neurobiol Aging. 2018. PMID: 30078640 Free PMC article.
SORLA Expression in Synaptic Plexiform Layers of Mouse Retina.
Monti G, Jensen ML, Mehmedbasic A, Jørgensen MM, Holm IE, Barkholt P, Zole E, Vægter CB, Vorum H, Nyengaard JR, Andersen OM. Monti G, et al. Among authors: andersen om. Mol Neurobiol. 2020 Jul;57(7):3106-3117. doi: 10.1007/s12035-020-01946-x. Epub 2020 May 29. Mol Neurobiol. 2020. PMID: 32472518
Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease.
Monti G, Kjolby M, Jensen AMG, Allen M, Reiche J, Møller PL, Comaposada-Baró R, Zolkowski BE, Vieira C, Jørgensen MM, Holm IE, Valdmanis PN, Wellner N, Vægter CB, Lincoln SJ, Nykjær A, Ertekin-Taner N, Young JE, Nyegaard M, Andersen OM. Monti G, et al. Among authors: andersen om. Acta Neuropathol Commun. 2021 Mar 16;9(1):43. doi: 10.1186/s40478-021-01140-7. Acta Neuropathol Commun. 2021. PMID: 33726851 Free PMC article.
Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling.
Simoes S, Guo J, Buitrago L, Qureshi YH, Feng X, Kothiya M, Cortes E, Patel V, Kannan S, Kim YH, Chang KT; Alzheimer's Disease Neuroimaging Initiative; Hussaini SA, Moreno H, Di Paolo G, Andersen OM, Small SA. Simoes S, et al. Among authors: andersen om. Cell Rep. 2021 Dec 28;37(13):110182. doi: 10.1016/j.celrep.2021.110182. Cell Rep. 2021. PMID: 34965419 Free PMC article.
96 results