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Design and recruitment for the GAP trial, investigating the preventive effect on asthma development of an SQ-standardized grass allergy immunotherapy tablet in children with grass pollen-induced allergic rhinoconjunctivitis.
Valovirta E, Berstad AK, de Blic J, Bufe A, Eng P, Halken S, Ojeda P, Roberts G, Tommerup L, Varga EM, Winnergard I; GAP investigators. Valovirta E, et al. Clin Ther. 2011 Oct;33(10):1537-46. doi: 10.1016/j.clinthera.2011.09.013. Epub 2011 Oct 13. Clin Ther. 2011. PMID: 21999887 Clinical Trial.
Protein-ligand interactions in the lysine-binding site of plasminogen kringle 4 are different in crystal and solution. Electrostatic interactions studied by site-directed mutagenesis exclude Lys35 as an important acceptor in solution.
Nielsen PR, Einer-Jensen K, Holtet TL, Andersen BD, Poulsen FM, Thøgersen HC. Nielsen PR, et al. Among authors: andersen bd. Biochemistry. 1993 Dec 7;32(48):13019-25. doi: 10.1021/bi00211a010. Biochemistry. 1993. PMID: 8241155
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