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1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carrying the FGFR3 gene mutation along with up-regulation of p27/Kip1 and G1/G0 arrest.
Miyake M, Ishii M, Koyama N, Kawashima K, Kodama T, Anai S, Fujimoto K, Hirao Y, Sugano K. Miyake M, et al. Among authors: anai s. J Pharmacol Exp Ther. 2010 Mar;332(3):795-802. doi: 10.1124/jpet.109.162768. Epub 2009 Dec 2. J Pharmacol Exp Ther. 2010. PMID: 19955487
Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma.
Hotta K, Sho M, Fujimoto K, Shimada K, Yamato I, Anai S, Konishi N, Hirao Y, Nonomura K, Nakajima Y. Hotta K, et al. Among authors: anai s. Br J Cancer. 2011 Oct 11;105(8):1191-6. doi: 10.1038/bjc.2011.368. Epub 2011 Sep 20. Br J Cancer. 2011. PMID: 21934683 Free PMC article.
205 results