Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis.
An Y, Zhang H, Wang C, Jiao F, Xu H, Wang X, Luan W, Ma F, Ni L, Tang X, Liu M, Guo W, Yu L.
An Y, et al.
FASEB J. 2019 Nov;33(11):12515-12527. doi: 10.1096/fj.201802805RR. Epub 2019 Aug 28.
FASEB J. 2019.
PMID: 31461386
Free PMC article.
We found that high glucose (HG) conditions induced the production of reactive oxygen species (ROS) and the expression of proteins related to MAPKs [phosphorylated (p)-ERK, p-JNK, and p-p38], NF-kappaB (NF-kappaB, p-IkappaB, and IKK), and NACHT-LRR-PYD domains-containing protein 3 …
We found that high glucose (HG) conditions induced the production of reactive oxygen species (ROS) and the expression of proteins related to …