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Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.
An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P, Zhang P, Yu X, Sun JP. An W, et al. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2117004119. doi: 10.1073/pnas.2117004119. Epub 2022 Apr 8. Proc Natl Acad Sci U S A. 2022. PMID: 35394864 Free PMC article.
In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals.
Lin JY, Cheng J, Du YQ, Pan W, Zhang Z, Wang J, An J, Yang F, Xu YF, Lin H, An WT, Wang J, Yang Z, Chai RJ, Sha XY, Hu HL, Sun JP, Yu X. Lin JY, et al. Among authors: an wt, an j. Cell Discov. 2020 Apr 7;6:20. doi: 10.1038/s41421-020-0159-x. eCollection 2020. Cell Discov. 2020. PMID: 32284878 Free PMC article.
Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology.
Sun Y, Zhang D, Ma ML, Lin H, Song Y, Wang J, Ma C, Yu K, An W, Guo S, He D, Yang Z, Xiao P, Hou G, Yu X, Sun JP. Sun Y, et al. Among authors: an w. J Biol Chem. 2021 Jan-Jun;296:100174. doi: 10.1074/jbc.RA120.014726. Epub 2020 Dec 17. J Biol Chem. 2021. PMID: 33303626 Free PMC article.
We next designed systematic strategies to optimize the peptide agonist of ADGRG2, using natural and unnatural amino acid substitutions. We obtained an optimized ADGRG2 Stachel peptide T1V/F3Phe(4-Me) (VPM-p15) that activated ADGRG2 with significantly improved (>2 orders …
We next designed systematic strategies to optimize the peptide agonist of ADGRG2, using natural and unnatural amino acid substitutions. We o …
Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex.
Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP. Ping YQ, et al. Nature. 2021 Jan;589(7843):620-626. doi: 10.1038/s41586-020-03083-w. Epub 2021 Jan 6. Nature. 2021. PMID: 33408414
The steroidal core of glucocorticoids is packed against the 'toggle switch' residue W(6.53), which senses the binding of a ligand and induces activation of the receptor. ...Our work provides a structural basis for ligand binding to the seven-transmembrane domain of an …
The steroidal core of glucocorticoids is packed against the 'toggle switch' residue W(6.53), which senses the binding of a ligand and …
Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment.
Guan Y, Du HB, Yang Z, Wang YZ, Ren R, Liu WW, Zhang C, Zhang JH, An WT, Li NN, Zeng XX, Li J, Sun YX, Wang YF, Yang F, Yang J, Xiong W, Yu X, Chai RJ, Tu XM, Sun JP, Xu ZG. Guan Y, et al. Among authors: an wt. Adv Sci (Weinh). 2023 Jun;10(16):e2205993. doi: 10.1002/advs.202205993. Epub 2023 Apr 17. Adv Sci (Weinh). 2023. PMID: 37066759 Free PMC article.
1,250 results