Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs.
Yang Y, Wu H, Kang X, Liang Y, Lan T, Li T, Tan T, Peng J, Zhang Q, An G, Liu Y, Yu Q, Ma Z, Lian Y, Soh BS, Chen Q, Liu P, Chen Y, Sun X, Li R, Zhen X, Liu P, Yu Y, Li X, Fan Y.
Yang Y, et al. Among authors: an g.
Protein Cell. 2018 Mar;9(3):283-297. doi: 10.1007/s13238-017-0499-y. Epub 2018 Jan 9.
Protein Cell. 2018.
PMID: 29318513
Free PMC article.
We engineered mitochondrial-targeted transcription activator-like effector nucleases (mitoTALENs) and successfully eliminated the m.3243A>G mutation in MiPSCs. Off-target mutagenesis was not detected in the targeted MiPSC clones. ...Furthermore, we successfully achieved …
We engineered mitochondrial-targeted transcription activator-like effector nucleases (mitoTALENs) and successfully eliminated the m.3243A> …