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Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?
Toxins (Basel). 2019 Jun 18;11(6):354. doi: 10.3390/toxins11060354.
Toxins (Basel). 2019.
PMID: 31216745
Free PMC article.
Review.
Cholesterol stimulates the lytic activity of Adenylate Cyclase Toxin on lipid membranes by promoting toxin oligomerization and formation of pores with a greater effective size.
González Bullón D, Uribe KB, Amuategi J, Martín C, Ostolaza H.
González Bullón D, et al. Among authors: amuategi j.
FEBS J. 2021 Dec;288(23):6795-6814. doi: 10.1111/febs.16107. Epub 2021 Jul 14.
FEBS J. 2021.
PMID: 34216517
Free PMC article.
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Four Cholesterol-Recognition Motifs in the Pore-Forming and Translocation Domains of Adenylate Cyclase Toxin Are Essential for Invasion of Eukaryotic Cells and Lysis of Erythrocytes.
Amuategi J, Alonso R, Ostolaza H.
Amuategi J, et al.
Int J Mol Sci. 2022 Aug 5;23(15):8703. doi: 10.3390/ijms23158703.
Int J Mol Sci. 2022.
PMID: 35955837
Free PMC article.
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Membrane Interaction Characteristics of the RTX Toxins and the Cholesterol-Dependence of Their Cytolytic/Cytotoxic Activity.
Ostolaza H, Amuategi J.
Ostolaza H, et al. Among authors: amuategi j.
Int J Mol Sci. 2024 Mar 8;25(6):3131. doi: 10.3390/ijms25063131.
Int J Mol Sci. 2024.
PMID: 38542105
Free PMC article.
Review.
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