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Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest.
Vitale RM, D'Aniello E, Gorbi S, Martella A, Silvestri C, Giuliani ME, Fellous T, Gentile A, Carbone M, Cutignano A, Grauso L, Magliozzi L, Polese G, D'Aniello B, Defranoux F, Felline S, Terlizzi A, Calignano A, Regoli F, Di Marzo V, Amodeo P, Mollo E. Vitale RM, et al. Among authors: amodeo p. Mar Drugs. 2018 Nov 3;16(11):431. doi: 10.3390/md16110431. Mar Drugs. 2018. PMID: 30400299 Free PMC article.
Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach.
D'Aniello E, Fellous T, Iannotti FA, Gentile A, Allarà M, Balestrieri F, Gray R, Amodeo P, Vitale RM, Di Marzo V. D'Aniello E, et al. Among authors: amodeo p. Biochim Biophys Acta Gen Subj. 2019 Mar;1863(3):586-597. doi: 10.1016/j.bbagen.2019.01.002. Epub 2019 Jan 3. Biochim Biophys Acta Gen Subj. 2019. PMID: 30611848
In Silico Identification and Experimental Validation of (-)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator.
D'Aniello E, Iannotti FA, Falkenberg LG, Martella A, Gentile A, De Maio F, Ciavatta ML, Gavagnin M, Waxman JS, Di Marzo V, Amodeo P, Vitale RM. D'Aniello E, et al. Among authors: amodeo p. Mar Drugs. 2019 Feb 12;17(2):110. doi: 10.3390/md17020110. Mar Drugs. 2019. PMID: 30759808 Free PMC article.
Minimalist hybrid ligand/receptor-based pharmacophore model for CXCR4 applied to a small-library of marine natural products led to the identification of phidianidine a as a new CXCR4 ligand exhibiting antagonist activity.
Vitale RM, Gatti M, Carbone M, Barbieri F, Felicità V, Gavagnin M, Florio T, Amodeo P. Vitale RM, et al. Among authors: amodeo p. ACS Chem Biol. 2013 Dec 20;8(12):2762-70. doi: 10.1021/cb400521b. Epub 2013 Oct 30. ACS Chem Biol. 2013. PMID: 24102412
106 results