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Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
J Med Chem. 2023 Apr 27;66(8):5453-5464. doi: 10.1021/acs.jmedchem.2c01773. Epub 2023 Apr 12.
J Med Chem. 2023.
PMID: 37043436
Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring.
Iio K, Saitoh T, Ohshita R, Hino T, Amezawa M, Takayama Y, Nagumo Y, Yamamoto N, Kutsumura N, Irukayama-Tomobe Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
Iio K, et al. Among authors: amezawa m.
Bioorg Med Chem Lett. 2022 Mar 15;60:128555. doi: 10.1016/j.bmcl.2022.128555. Epub 2022 Jan 17.
Bioorg Med Chem Lett. 2022.
PMID: 35051577
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Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.
Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H, Tanimura R, Yanagisawa M, Nagase H.
Saitoh T, et al. Among authors: amezawa m.
Eur J Med Chem. 2022 Oct 5;240:114505. doi: 10.1016/j.ejmech.2022.114505. Epub 2022 Jun 13.
Eur J Med Chem. 2022.
PMID: 35839689
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Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5‑trioxazatriquinane skeleton.
Amezawa M, Yamamoto N, Nagumo Y, Kutsumura N, Ishikawa Y, Yanagisawa M, Nagase H, Saitoh T.
Amezawa M, et al.
Bioorg Med Chem Lett. 2023 Feb 15;82:129151. doi: 10.1016/j.bmcl.2023.129151. Epub 2023 Jan 20.
Bioorg Med Chem Lett. 2023.
PMID: 36690040
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Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice.
Lin Y, Roy K, Ioka S, Otani R, Amezawa M, Ishikawa Y, Cherasse Y, Kaushik MK, Klewe-Nebenius D, Zhou L, Yanagisawa M, Oishi Y, Saitoh T, Lazarus M.
Lin Y, et al. Among authors: amezawa m.
Front Pharmacol. 2023 Apr 19;14:1138666. doi: 10.3389/fphar.2023.1138666. eCollection 2023.
Front Pharmacol. 2023.
PMID: 37153764
Free PMC article.
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Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors.
Roy K, Zhou X, Otani R, Yuan PC, Ioka S, Vogt KE, Kondo T, Farag NHT, Ijiri H, Wu Z, Chitose Y, Amezawa M, Uygun DS, Cherasse Y, Nagase H, Li Y, Yanagisawa M, Abe M, Basheer R, Wang YQ, Saitoh T, Lazarus M.
Roy K, et al. Among authors: amezawa m.
Nat Commun. 2024 Apr 30;15(1):3661. doi: 10.1038/s41467-024-47964-4.
Nat Commun. 2024.
PMID: 38688901
Free PMC article.
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Components of the metabolic syndrome and lifestyle factors in Japanese male workers.
Kawada T, Okada K, Amezawa M.
Kawada T, et al. Among authors: amezawa m.
Metab Syndr Relat Disord. 2008 Dec;6(4):263-6. doi: 10.1089/met.2008.0020.
Metab Syndr Relat Disord. 2008.
PMID: 19067529
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Effects of exercise and serum uric acid on the metabolic syndrome for Japanese workers.
Kawada T, Amezawa M.
Kawada T, et al. Among authors: amezawa m.
Metab Syndr Relat Disord. 2008 Jun;6(2):137-41. doi: 10.1089/met.2008.0011.
Metab Syndr Relat Disord. 2008.
PMID: 18510437
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