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De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors.
Wang Y, Zhao H, Brewer JT, Li H, Lao Y, Amberg W, Behl B, Akritopoulou-Zanze I, Dietrich J, Lange UEW, Pohlki F, Hoft C, Hornberger W, Djuric SW, Sydor J, Mezler M, Relo AL, Vasudevan A. Wang Y, et al. Among authors: amberg w. J Med Chem. 2018 Sep 13;61(17):7486-7502. doi: 10.1021/acs.jmedchem.8b00295. Epub 2018 Jul 17. J Med Chem. 2018. PMID: 29969029
Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors.
Amberg W, Lange UEW, Ochse M, Pohlki F, Behl B, Relo AL, Hornberger W, Hoft C, Mezler M, Sydor J, Wang Y, Zhao H, Brewer JT, Dietrich J, Li H, Akritopoulou-Zanze I, Lao Y, Hannick SM, Ku YY, Vasudevan A. Amberg W, et al. J Med Chem. 2018 Sep 13;61(17):7503-7524. doi: 10.1021/acs.jmedchem.8b00300. Epub 2018 Aug 27. J Med Chem. 2018. PMID: 30080045
Solid-phase synthesis of endothelin receptor antagonists.
Lange UE, Braje WM, Amberg W, Kettschau G. Lange UE, et al. Among authors: amberg w. Bioorg Med Chem Lett. 2003 May 19;13(10):1721-4. doi: 10.1016/s0960-894x(03)00236-1. Bioorg Med Chem Lett. 2003. PMID: 12729650
Inhibitors of GlyT1 affect glycine transport via discrete binding sites.
Mezler M, Hornberger W, Mueller R, Schmidt M, Amberg W, Braje W, Ochse M, Schoemaker H, Behl B. Mezler M, et al. Among authors: amberg w. Mol Pharmacol. 2008 Dec;74(6):1705-15. doi: 10.1124/mol.108.049312. Epub 2008 Sep 24. Mol Pharmacol. 2008. PMID: 18815213
Pharmacological mTOR-inhibition facilitates clearance of AD-related tau aggregates in the mouse brain.
Morawe MP, Liao F, Amberg W, van Bergeijk J, Chang R, Gulino M, Hamilton C, Hoft C, Lumpkin C, Mastis B, McGlame E, Nuber J, Plaas C, Ravikumar B, Roy K, Schanzenbächer M, Tierno J, Lakics V, Dellovade T, Townsend M. Morawe MP, et al. Among authors: amberg w. Eur J Pharmacol. 2022 Nov 5;934:175301. doi: 10.1016/j.ejphar.2022.175301. Epub 2022 Sep 30. Eur J Pharmacol. 2022. PMID: 36191631 Free article.
Computational prediction of chemical reactions: current status and outlook.
Engkvist O, Norrby PO, Selmi N, Lam YH, Peng Z, Sherer EC, Amberg W, Erhard T, Smyth LA. Engkvist O, et al. Among authors: amberg w. Drug Discov Today. 2018 Jun;23(6):1203-1218. doi: 10.1016/j.drudis.2018.02.014. Epub 2018 Mar 3. Drug Discov Today. 2018. PMID: 29510217 Review.
Total Synthesis of (+)-Euphorikanin A via an Atropospecific Cascade.
Classen MJ, Kicin B, Ruf VAP, Hamminger A, Ribadeau-Dumas L, Amberg WM, Carreira EM. Classen MJ, et al. Among authors: amberg wm. J Am Chem Soc. 2023 Dec 20;145(50):27225-27229. doi: 10.1021/jacs.3c11000. Epub 2023 Dec 5. J Am Chem Soc. 2023. PMID: 38051111 Free PMC article.
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