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Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension.
Prinsen JK, Kannankeril PJ, Sidorova TN, Yermalitskaya LV, Boutaud O, Zagol-Ikapitte I, Barnett JV, Murphy MB, Subati T, Stark JM, Christopher IL, Jafarian-Kerman SR, Saleh MA, Norlander AE, Loperena R, Atkinson JB, Fogo AB, Luther JM, Amarnath V, Davies SS, Kirabo A, Madhur MS, Harrison DG, Murray KT. Prinsen JK, et al. Among authors: amarnath v. JACC Basic Transl Sci. 2020 May 27;5(6):602-615. doi: 10.1016/j.jacbts.2020.04.004. eCollection 2020 Jun. JACC Basic Transl Sci. 2020. PMID: 32613146 Free PMC article.
Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells.
Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ 2nd, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT. Sidorova TN, et al. Among authors: amarnath v. J Mol Cell Cardiol. 2015 Feb;79:295-302. doi: 10.1016/j.yjmcc.2014.11.013. Epub 2014 Nov 18. J Mol Cell Cardiol. 2015. PMID: 25463275 Free PMC article.
Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension.
Dikalova A, Mayorov V, Xiao L, Panov A, Amarnath V, Zagol-Ikapitte I, Vergeade A, Ao M, Yermalitsky V, Nazarewicz RR, Boutaud O, Lopez MG, Billings FT 4th, Davies S, Roberts LJ 2nd, Harrison DG, Dikalov S. Dikalova A, et al. Among authors: amarnath v. Hypertension. 2020 Dec;76(6):1980-1991. doi: 10.1161/HYPERTENSIONAHA.120.15236. Epub 2020 Oct 5. Hypertension. 2020. PMID: 33012204 Free PMC article.
Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus.
Patrick DM, de la Visitación N, Krishnan J, Chen W, Ormseth MJ, Stein CM, Davies SS, Amarnath V, Crofford LJ, Williams JM, Zhao S, Smart CD, Dikalov S, Dikalova A, Xiao L, Van Beusecum JP, Ao M, Fogo AB, Kirabo A, Harrison DG. Patrick DM, et al. Among authors: amarnath v. JCI Insight. 2022 Jul 8;7(13):e136678. doi: 10.1172/jci.insight.136678. JCI Insight. 2022. PMID: 35608913 Free PMC article.
113 results