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A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants.
Modhiran N, Lauer SM, Amarilla AA, Hewins P, Lopes van den Broek SI, Low YS, Thakur N, Liang B, Nieto GV, Jung J, Paramitha D, Isaacs A, Sng JDJ, Song D, Jørgensen JT, Cheuquemilla Y, Bürger J, Andersen IV, Himelreichs J, Jara R, MacLoughlin R, Miranda-Chacon Z, Chana-Cuevas P, Kramer V, Spahn C, Mielke T, Khromykh AA, Munro T, Jones ML, Young PR, Chappell K, Bailey D, Kjaer A, Herth MM, Jurado KA, Schwefel D, Rojas-Fernandez A, Watterson D. Modhiran N, et al. Among authors: amarilla aa. iScience. 2023 Jun 9;26(7):107085. doi: 10.1016/j.isci.2023.107085. eCollection 2023 Jul 21. iScience. 2023. PMID: 37361875 Free PMC article.
Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody.
Valenzuela Nieto G, Jara R, Watterson D, Modhiran N, Amarilla AA, Himelreichs J, Khromykh AA, Salinas-Rebolledo C, Pinto T, Cheuquemilla Y, Margolles Y, López González Del Rey N, Miranda-Chacon Z, Cuevas A, Berking A, Deride C, González-Moraga S, Mancilla H, Maturana D, Langer A, Toledo JP, Müller A, Uberti B, Krall P, Ehrenfeld P, Blesa J, Chana-Cuevas P, Rehren G, Schwefel D, Fernandez LÁ, Rojas-Fernandez A. Valenzuela Nieto G, et al. Among authors: amarilla aa. Sci Rep. 2021 Feb 8;11(1):3318. doi: 10.1038/s41598-021-82833-w. Sci Rep. 2021. PMID: 33558635 Free PMC article.
An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2.
Amarilla AA, Modhiran N, Setoh YX, Peng NYG, Sng JDJ, Liang B, McMillan CLD, Freney ME, Cheung STM, Chappell KJ, Khromykh AA, Young PR, Watterson D. Amarilla AA, et al. Front Microbiol. 2021 Feb 12;12:625136. doi: 10.3389/fmicb.2021.625136. eCollection 2021. Front Microbiol. 2021. PMID: 33643253 Free PMC article.
Dermal Delivery of a SARS-CoV-2 Subunit Vaccine Induces Immunogenicity against Variants of Concern.
McMillan CLD, Azuar A, Choo JJY, Modhiran N, Amarilla AA, Isaacs A, Honeyman KE, Cheung STM, Liang B, Wurm MJ, Pino P, Kint J, Fernando GJP, Landsberg MJ, Khromykh AA, Hobson-Peters J, Watterson D, Young PR, Muller DA. McMillan CLD, et al. Among authors: amarilla aa. Vaccines (Basel). 2022 Apr 8;10(4):578. doi: 10.3390/vaccines10040578. Vaccines (Basel). 2022. PMID: 35455326 Free PMC article.
Nucleocapsid Specific Diagnostics for the Detection of Divergent SARS-CoV-2 Variants.
Isaacs A, Amarilla AA, Aguado J, Modhiran N, Albornoz EA, Baradar AA, McMillan CLD, Choo JJY, Idris A, Supramaniam A, McMillan NAJ, Muller DA, Young PR, Woodruff TM, Wolvetang EJ, Chappell KJ, Watterson D. Isaacs A, et al. Among authors: amarilla aa. Front Immunol. 2022 Jun 10;13:926262. doi: 10.3389/fimmu.2022.926262. eCollection 2022. Front Immunol. 2022. PMID: 35757714 Free PMC article.
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.
Albornoz EA, Amarilla AA, Modhiran N, Parker S, Li XX, Wijesundara DK, Aguado J, Zamora AP, McMillan CLD, Liang B, Peng NYG, Sng JDJ, Saima FT, Fung JN, Lee JD, Paramitha D, Parry R, Avumegah MS, Isaacs A, Lo MW, Miranda-Chacon Z, Bradshaw D, Salinas-Rebolledo C, Rajapakse NW, Wolvetang EJ, Munro TP, Rojas-Fernandez A, Young PR, Stacey KJ, Khromykh AA, Chappell KJ, Watterson D, Woodruff TM. Albornoz EA, et al. Among authors: amarilla aa. Mol Psychiatry. 2023 Jul;28(7):2878-2893. doi: 10.1038/s41380-022-01831-0. Epub 2022 Nov 1. Mol Psychiatry. 2023. PMID: 36316366 Free PMC article.
Monoclonal Antibodies Specific for SARS-CoV-2 Spike Protein Suitable for Multiple Applications for Current Variants of Concern.
Morgan MS, Yan K, Le TT, Johnston RA, Amarilla AA, Muller DA, McMillan CLD, Modhiran N, Watterson D, Potter JR, Sng JDJ, Lor M, Paramitha D, Isaacs A, Khromykh AA, Hall RA, Suhrbier A, Rawle DJ, Hobson-Peters J. Morgan MS, et al. Among authors: amarilla aa. Viruses. 2022 Dec 31;15(1):139. doi: 10.3390/v15010139. Viruses. 2022. PMID: 36680179 Free PMC article.
Complete protection by a single-dose skin patch-delivered SARS-CoV-2 spike vaccine.
McMillan CLD, Choo JJY, Idris A, Supramaniam A, Modhiran N, Amarilla AA, Isaacs A, Cheung STM, Liang B, Bielefeldt-Ohmann H, Azuar A, Acharya D, Kelly G, Fernando GJP, Landsberg MJ, Khromykh AA, Watterson D, Young PR, McMillan NAJ, Muller DA. McMillan CLD, et al. Among authors: amarilla aa. Sci Adv. 2021 Oct 29;7(44):eabj8065. doi: 10.1126/sciadv.abj8065. Epub 2021 Oct 29. Sci Adv. 2021. PMID: 34714668 Free PMC article.
65 results