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Impaired cortico-striatal excitatory transmission triggers epilepsy.
Miyamoto H, Tatsukawa T, Shimohata A, Yamagata T, Suzuki T, Amano K, Mazaki E, Raveau M, Ogiwara I, Oba-Asaka A, Hensch TK, Itohara S, Sakimura K, Kobayashi K, Kobayashi K, Yamakawa K. Miyamoto H, et al. Among authors: amano k. Nat Commun. 2019 Apr 23;10(1):1917. doi: 10.1038/s41467-019-09954-9. Nat Commun. 2019. PMID: 31015467 Free PMC article.
Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice.
Ganesh S, Delgado-Escueta AV, Sakamoto T, Avila MR, Machado-Salas J, Hoshii Y, Akagi T, Gomi H, Suzuki T, Amano K, Agarwala KL, Hasegawa Y, Bai DS, Ishihara T, Hashikawa T, Itohara S, Cornford EM, Niki H, Yamakawa K. Ganesh S, et al. Among authors: amano k. Hum Mol Genet. 2002 May 15;11(11):1251-62. doi: 10.1093/hmg/11.11.1251. Hum Mol Genet. 2002. PMID: 12019206
Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K. Shimohata A, et al. Among authors: amano k. Exp Neurol. 2017 Jul;293:1-12. doi: 10.1016/j.expneurol.2017.03.009. Epub 2017 Mar 20. Exp Neurol. 2017. PMID: 28336394
Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABAB receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice.
Arima-Yoshida F, Raveau M, Shimohata A, Amano K, Fukushima A, Watanave M, Kobayashi S, Hattori S, Usui M, Sago H, Mataga N, Miyakawa T, Yamakawa K, Manabe T. Arima-Yoshida F, et al. Among authors: amano k. Sci Rep. 2020 Aug 25;10(1):14187. doi: 10.1038/s41598-020-71085-9. Sci Rep. 2020. PMID: 32843708 Free PMC article.
1,331 results