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The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation.
J Biol Chem. 2021 Dec;297(6):101314. doi: 10.1016/j.jbc.2021.101314. Epub 2021 Oct 27.
J Biol Chem. 2021.
PMID: 34715128
Free PMC article.
Incorporation of Ni2+, Co2+, and Selenocysteine into the Auxiliary Fe-S Cluster of the Radical SAM Enzyme HydG.
Rao G, Alwan KB, Blackburn NJ, Britt RD.
Rao G, et al. Among authors: alwan kb.
Inorg Chem. 2019 Oct 7;58(19):12601-12608. doi: 10.1021/acs.inorgchem.9b01293. Epub 2019 Sep 20.
Inorg Chem. 2019.
PMID: 31539235
Free PMC article.
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Rational Design of a Histidine-Methionine Site Modeling the M-Center of Copper Monooxygenases in a Small Metallochaperone Scaffold.
Alwan KB, Welch EF, Arias RJ, Gambill BF, Blackburn NJ.
Alwan KB, et al.
Biochemistry. 2019 Jul 16;58(28):3097-3108. doi: 10.1021/acs.biochem.9b00312. Epub 2019 Jun 27.
Biochemistry. 2019.
PMID: 31243953
Free PMC article.
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Catalytic M Center of Copper Monooxygenases Probed by Rational Design. Effects of Selenomethionine and Histidine Substitution on Structure and Reactivity.
Alwan KB, Welch EF, Blackburn NJ.
Alwan KB, et al.
Biochemistry. 2019 Nov 5;58(44):4436-4446. doi: 10.1021/acs.biochem.9b00823. Epub 2019 Oct 28.
Biochemistry. 2019.
PMID: 31626532
Free PMC article.
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The binuclear cluster of [FeFe] hydrogenase is formed with sulfur donated by cysteine of an [Fe(Cys)(CO)2(CN)] organometallic precursor.
Rao G, Pattenaude SA, Alwan K, Blackburn NJ, Britt RD, Rauchfuss TB.
Rao G, et al.
Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20850-20855. doi: 10.1073/pnas.1913324116. Epub 2019 Sep 30.
Proc Natl Acad Sci U S A. 2019.
PMID: 31570604
Free PMC article.
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Trapping intermediates in metal transfer reactions of the CusCBAF export pump of Escherichia coli.
Chacón KN, Perkins J, Mathe Z, Alwan K, Ho EN, Ucisik MN, Merz KM, Blackburn NJ.
Chacón KN, et al.
Commun Biol. 2018 Nov 14;1:192. doi: 10.1038/s42003-018-0181-9. eCollection 2018.
Commun Biol. 2018.
PMID: 30456313
Free PMC article.
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