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244 results

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Page 1
Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists.
Reger TS, Zunic J, Stock N, Wang B, Smith ND, Munoz B, Green MD, Gardner MF, James JP, Chen W, Alves K, Si Q, Treonze KM, Lingham RB, Mumford RA. Reger TS, et al. Among authors: alves k. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1173-6. doi: 10.1016/j.bmcl.2009.12.009. Epub 2009 Dec 4. Bioorg Med Chem Lett. 2010. PMID: 20022493
Influence of acid surrogates toward potency of VLA-4 antagonist.
Venkatraman S, Lim J, Cramer M, Gardner MF, James J, Alves K, Lingham RB, Mumford RA, Munoz B. Venkatraman S, et al. Among authors: alves k. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4053-6. doi: 10.1016/j.bmcl.2005.06.034. Bioorg Med Chem Lett. 2005. PMID: 16039122
Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Venkatraman S, Lebsack AD, Alves K, Gardner MF, James J, Lingham RB, Maniar S, Mumford RA, Si Q, Stock N, Treonze KM, Wang B, Zunic J, Munoz B. Venkatraman S, et al. Among authors: alves k. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5803-6. doi: 10.1016/j.bmcl.2009.07.111. Epub 2009 Jul 28. Bioorg Med Chem Lett. 2009. PMID: 19713111
Characterization of alpha(4)beta(1) (CD49d/CD29) on equine leukocytes: potential utility of a potent alpha(4)beta(1) (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction).
Treonze KM, Alves K, Fischer P, Hagmann WK, Hora D, Kulick A, Vakerich K, Smith ND, Lingham RB, Maniar S, Reger TS, Zunic J, Munoz B, Prasit P, Nicholson D, Si Q, Judd K, Nicolich S, Kellerhouse P, Thompson D, Mumford RA. Treonze KM, et al. Among authors: alves k. Vet Immunol Immunopathol. 2009 Jul 15;130(1-2):79-87. doi: 10.1016/j.vetimm.2009.01.011. Epub 2009 Feb 4. Vet Immunol Immunopathol. 2009. PMID: 19250687
Multiplexed assays by high-content imaging for assessment of GPCR activity.
Ross DA, Lee S, Reiser V, Xue J, Alves K, Vaidya S, Kreamer A, Mull R, Hudak E, Hare T, Detmers PA, Lingham R, Ferrer M, Strulovici B, Santini F. Ross DA, et al. Among authors: alves k. J Biomol Screen. 2008 Jul;13(6):449-55. doi: 10.1177/1087057108317685. Epub 2008 Jun 2. J Biomol Screen. 2008. PMID: 18519922
Characterization of cloned human endothelin receptors.
Williams DL Jr, Jones KL, Alves K, Chan CP, Hollis GF, Tung JS. Williams DL Jr, et al. Among authors: alves k. Life Sci. 1993;53(5):407-14. doi: 10.1016/0024-3205(93)90644-i. Life Sci. 1993. PMID: 8336519
Molecular cloning of the human fertilin beta subunit.
Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF. Gupta SK, et al. Among authors: alves k. Biochem Biophys Res Commun. 1996 Jul 16;224(2):318-26. doi: 10.1006/bbrc.1996.1027. Biochem Biophys Res Commun. 1996. PMID: 8702389
244 results