Alves AJS - Search Results

1

Spiro-Lactams as Novel Antimicrobial Agents.

Alves AJS, Alves NG, Caratão CC, Esteves MIM, Fontinha D, Bártolo I, Soares MIL, Lopes SMM, Prudêncio M, Taveira N, Pinho E Melo TMVD. Alves AJS, et al. Curr Top Med Chem. 2020;20(2):140-152. doi: 10.2174/1568026619666191105110049. Curr Top Med Chem. 2020. PMID: 31702503

2

Spiro-β-lactam BSS-730A Displays Potent Activity against HIV and Plasmodium.

Bártolo I, Santos BS, Fontinha D, Machado M, Francisco D, Sepodes B, Rocha J, Mota-Filipe H, Pinto R, Figueira ME, Barroso H, Nascimento T, Alves de Matos AP, Alves AJS, Alves NG, Simões CJV, Prudêncio M, Pinho E Melo TMVD, Taveira N. Bártolo I, et al. Among authors: alves ajs. ACS Infect Dis. 2021 Feb 12;7(2):421-434. doi: 10.1021/acsinfecdis.0c00768. Epub 2021 Jan 4. ACS Infect Dis. 2021. PMID: 33395253

3

Synthesis and structure-activity relationships of new chiral spiro-β-lactams highly active against HIV-1 and Plasmodium.

Alves NG, Bártolo I, Alves AJS, Fontinha D, Francisco D, Lopes SMM, Soares MIL, Simões CJV, Prudêncio M, Taveira N, Pinho E Melo TMVD. Alves NG, et al. Among authors: alves ajs. Eur J Med Chem. 2021 Jul 5;219:113439. doi: 10.1016/j.ejmech.2021.113439. Epub 2021 Apr 8. Eur J Med Chem. 2021. PMID: 33887681

4

Insights into the anticancer activity of chiral alkylidene-β-lactams and alkylidene-γ-lactams: Synthesis and biological investigation.

Alves AJS, Alves NG, Laranjo M, Gomes CSB, Cristina Gonçalves A, Bela Sarmento-Ribeiro A, Filomena Botelho M, Pinho E Melo TMVD. Alves AJS, et al. Bioorg Med Chem. 2022 Jun 1;63:116738. doi: 10.1016/j.bmc.2022.116738. Epub 2022 Apr 1. Bioorg Med Chem. 2022. PMID: 35421710

5

Unveiling a family of spiro-β-lactams with anti-HIV and antiplasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates.

Alves AJS, Alves NG, Bártolo I, Fontinha D, Caetano S, Prudêncio M, Taveira N, Pinho E Melo TMVD. Alves AJS, et al. Front Chem. 2022 Oct 7;10:1017250. doi: 10.3389/fchem.2022.1017250. eCollection 2022. Front Chem. 2022. PMID: 36277353 Free PMC article.

6

Synthesis of novel chiral spiro-β-lactams from nitrile oxides and 6-(Z)-(benzoylmethylene)penicillanate: batch, microwave-induced and continuous flow methodologies.

Alves AJS, Silvestre JAD, Pinho E Melo TMVD. Alves AJS, et al. RSC Adv. 2022 Oct 28;12(48):30879-30891. doi: 10.1039/d2ra04848e. eCollection 2022 Oct 27. RSC Adv. 2022. PMID: 36349033 Free PMC article.

7

High Instantaneous Inhibitory Potential of Bictegravir and the New Spiro-β-Lactam BSS-730A for HIV-2 Isolates from RAL-Naïve and RAL-Failing Patients.

Bártolo I, Moranguinho I, Gonçalves P, Diniz AR, Borrego P, Martin F, Figueiredo I, Gomes P, Gonçalves F, Alves AJS, Alves N, Caixas U, Pinto IV, Barahona I, Pinho E Melo TMVD, Taveira N. Bártolo I, et al. Among authors: alves ajs. Int J Mol Sci. 2022 Nov 18;23(22):14300. doi: 10.3390/ijms232214300. Int J Mol Sci. 2022. PMID: 36430777 Free PMC article.

8

Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.

Kim HO, Ahn SK, Alves AJ, Beach JW, Jeong LS, Choi BG, Van Roey P, Schinazi RF, Chu CK. Kim HO, et al. J Med Chem. 1992 May 29;35(11):1987-95. doi: 10.1021/jm00089a007. J Med Chem. 1992. PMID: 1597854

9

1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes.

Kim HO, Schinazi RF, Nampalli S, Shanmuganathan K, Cannon DL, Alves AJ, Jeong LS, Beach JW, Chu CK. Kim HO, et al. J Med Chem. 1993 Jan 8;36(1):30-7. doi: 10.1021/jm00053a004. J Med Chem. 1993. PMID: 8421287

10

Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.

Jeong LS, Schinazi RF, Beach JW, Kim HO, Nampalli S, Shanmuganathan K, Alves AJ, McMillan A, Chu CK, Mathis R. Jeong LS, et al. J Med Chem. 1993 Jan 22;36(2):181-95. doi: 10.1021/jm00054a001. J Med Chem. 1993. PMID: 8423591

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