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Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions.
Commun Chem. 2023 May 18;6(1):95. doi: 10.1038/s42004-023-00890-w.
Commun Chem. 2023.
PMID: 37202473
Free PMC article.
A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands.
Das S, Nag A, Liang J, Bunck DN, Umeda A, Farrow B, Coppock MB, Sarkes DA, Finch AS, Agnew HD, Pitram S, Lai B, Yu MB, Museth AK, Deyle KM, Lepe B, Rodriguez-Rivera FP, McCarthy A, Alvarez-Villalonga B, Chen A, Heath J, Stratis-Cullum DN, Heath JR.
Das S, et al. Among authors: alvarez villalonga b.
Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13219-24. doi: 10.1002/anie.201505243. Epub 2015 Sep 17.
Angew Chem Int Ed Engl. 2015.
PMID: 26377818
Free PMC article.
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