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Comparison of Proteomic Responses as Global Approach to Antibiotic Mechanism of Action Elucidation.
Senges CHR, Stepanek JJ, Wenzel M, Raatschen N, Ay Ü, Märtens Y, Prochnow P, Vázquez Hernández M, Yayci A, Schubert B, Janzing NBM, Warmuth HL, Kozik M, Bongard J, Alumasa JN, Albada B, Penkova M, Lukežič T, Sorto NA, Lorenz N, Miller RG, Zhu B, Benda M, Stülke J, Schäkermann S, Leichert LI, Scheinpflug K, Brötz-Oesterhelt H, Hertweck C, Shaw JT, Petković H, Brunel JM, Keiler KC, Metzler-Nolte N, Bandow JE. Senges CHR, et al. Among authors: alumasa jn. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01373-20. doi: 10.1128/AAC.01373-20. Print 2020 Dec 16. Antimicrob Agents Chemother. 2020. PMID: 33046497 Free PMC article.
Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics.
McGillivray SM, Tran DN, Ramadoss NS, Alumasa JN, Okumura CY, Sakoulas G, Vaughn MM, Zhang DX, Keiler KC, Nizet V. McGillivray SM, et al. Among authors: alumasa jn. Antimicrob Agents Chemother. 2012 Apr;56(4):1854-61. doi: 10.1128/AAC.05131-11. Epub 2012 Jan 17. Antimicrob Agents Chemother. 2012. PMID: 22252821 Free PMC article.
Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity.
Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H, Chatterjee AK, Brinker A, Engels IH, Keiler KC. Ramadoss NS, et al. Among authors: alumasa jn. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7. doi: 10.1073/pnas.1302816110. Epub 2013 Jun 3. Proc Natl Acad Sci U S A. 2013. PMID: 23733947 Free PMC article.
Clicking on trans-translation drug targets.
Alumasa JN, Keiler KC. Alumasa JN, et al. Front Microbiol. 2015 May 19;6:498. doi: 10.3389/fmicb.2015.00498. eCollection 2015. Front Microbiol. 2015. PMID: 26042115 Free PMC article. No abstract available.
Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication.
Goralski TD, Dewan KK, Alumasa JN, Avanzato V, Place DE, Markley RL, Katkere B, Rabadi SM, Bakshi CS, Keiler KC, Kirimanjeswara GS. Goralski TD, et al. Among authors: alumasa jn. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82. doi: 10.1128/AAC.03089-15. Print 2016 Jun. Antimicrob Agents Chemother. 2016. PMID: 26953190 Free PMC article.
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