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HIF1α-dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions.
Contreras-Lopez R, Elizondo-Vega R, Paredes MJ, Luque-Campos N, Torres MJ, Tejedor G, Vega-Letter AM, Figueroa-Valdés A, Pradenas C, Oyarce K, Jorgensen C, Khoury M, Garcia-Robles MLA, Altamirano C, Djouad F, Luz-Crawford P. Contreras-Lopez R, et al. Among authors: altamirano c. FASEB J. 2020 Jun;34(6):8250-8264. doi: 10.1096/fj.201902232R. Epub 2020 Apr 25. FASEB J. 2020. PMID: 32333618
PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties.
Contreras-Lopez RA, Elizondo-Vega R, Torres MJ, Vega-Letter AM, Luque-Campos N, Paredes-Martinez MJ, Pradenas C, Tejedor G, Oyarce K, Salgado M, Jorgensen C, Khoury M, Kronke G, Garcia-Robles MA, Altamirano C, Luz-Crawford P, Djouad F. Contreras-Lopez RA, et al. Among authors: altamirano c. Sci Rep. 2020 Jul 10;10(1):11423. doi: 10.1038/s41598-020-68347-x. Sci Rep. 2020. PMID: 32651456 Free PMC article.
The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential.
Contreras-Lopez R, Elizondo-Vega R, Luque-Campos N, Torres MJ, Pradenas C, Tejedor G, Paredes-Martínez MJ, Vega-Letter AM, Campos-Mora M, Rigual-Gonzalez Y, Oyarce K, Salgado M, Jorgensen C, Khoury M, Garcia-Robles MLÁ, Altamirano C, Djouad F, Luz-Crawford P. Contreras-Lopez R, et al. Among authors: altamirano c. Theranostics. 2021 Jan 1;11(1):445-460. doi: 10.7150/thno.51631. eCollection 2021. Theranostics. 2021. PMID: 33391485 Free PMC article.
Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells.
Pradenas C, Luque-Campos N, Oyarce K, Contreras-Lopez R, Bustamante-Barrientos FA, Bustos A, Galvez-Jiron F, Araya MJ, Asencio C, Lagos R, Herrera-Luna Y, Abba Moussa D, Hill CN, Lara-Barba E, Altamirano C, Ortloff A, Hidalgo-Fadic Y, Vega-Letter AM, García-Robles MLÁ, Djouad F, Luz-Crawford P, Elizondo-Vega R. Pradenas C, et al. Among authors: altamirano c. Stem Cell Res Ther. 2023 Nov 19;14(1):335. doi: 10.1186/s13287-023-03549-4. Stem Cell Res Ther. 2023. PMID: 37981698 Free PMC article.
77 results