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The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children.
Almén MS, Jacobsson JA, Shaik JH, Olszewski PK, Cedernaes J, Alsiö J, Sreedharan S, Levine AS, Fredriksson R, Marcus C, Schiöth HB. Almén MS, et al. Among authors: alsio j. BMC Med Genet. 2010 Apr 9;11:58. doi: 10.1186/1471-2350-11-58. BMC Med Genet. 2010. PMID: 20380707 Free PMC article.
Opioids as facilitators of feeding: can any food be rewarding?
Olszewski PK, Alsiö J, Schiöth HB, Levine AS. Olszewski PK, et al. Among authors: alsio j. Physiol Behav. 2011 Jul 25;104(1):105-10. doi: 10.1016/j.physbeh.2011.04.033. Epub 2011 Apr 28. Physiol Behav. 2011. PMID: 21536057 Review.
Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.
Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Strömberg S, Hans W, Klockars A, Alsiö J, Risérus U, Becker L, Hölter SM, Elvert R, Ehrhardt N, Gailus-Durner V, Fuchs H, Fredriksson R, Wolf E, Klopstock T, Wurst W, Levine AS, Marcus C, de Angelis MH, Klingenspor M, Schiöth HB, Kilimann MW. Olszewski PK, et al. Among authors: alsio j. PLoS Genet. 2012;8(3):e1002568. doi: 10.1371/journal.pgen.1002568. Epub 2012 Mar 15. PLoS Genet. 2012. PMID: 22438821 Free PMC article.
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