Alsford S - Search Results

1

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose.

Racané L, Ptiček L, Kostrun S, Raić-Malić S, Taylor MC, Delves M, Alsford S, Olmo F, Francisco AF, Kelly JM. Racané L, et al. Among authors: alsford s. J Med Chem. 2023 Sep 28;66(18):13043-13057. doi: 10.1021/acs.jmedchem.3c01051. Epub 2023 Sep 18. J Med Chem. 2023. PMID: 37722077 Free PMC article.

2

Genetic dissection of drug resistance in trypanosomes.

Alsford S, Kelly JM, Baker N, Horn D. Alsford S, et al. Parasitology. 2013 Oct;140(12):1478-91. doi: 10.1017/S003118201300022X. Epub 2013 Apr 3. Parasitology. 2013. PMID: 23552488 Free PMC article. Review.

3

Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy.

Alsford S, Field MC, Horn D. Alsford S, et al. Trends Parasitol. 2013 May;29(5):207-12. doi: 10.1016/j.pt.2013.03.004. Epub 2013 Apr 17. Trends Parasitol. 2013. PMID: 23601931

4

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.

Baker N, Alsford S, Horn D. Baker N, et al. Among authors: alsford s. Mol Biochem Parasitol. 2011 Mar;176(1):55-7. doi: 10.1016/j.molbiopara.2010.11.010. Epub 2010 Nov 18. Mol Biochem Parasitol. 2011. PMID: 21093499 Free PMC article.

5

High-throughput decoding of antitrypanosomal drug efficacy and resistance.

Alsford S, Eckert S, Baker N, Glover L, Sanchez-Flores A, Leung KF, Turner DJ, Field MC, Berriman M, Horn D. Alsford S, et al. Nature. 2012 Jan 25;482(7384):232-6. doi: 10.1038/nature10771. Nature. 2012. PMID: 22278056 Free PMC article.

6

Subverting lysosomal function in Trypanosoma brucei.

Alsford S. Alsford S. Microb Cell. 2015 Aug;2(8):259-261. doi: 10.15698/mic2015.08.222. Microb Cell. 2015. PMID: 27441200 Free PMC article.

7

Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis.

Alsford S. Alsford S. Microb Cell. 2014 Aug;1(8):270-272. doi: 10.15698/mic2014.08.162. Microb Cell. 2014. PMID: 27441199 Free PMC article.

Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an …

Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human se …

8

A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.

Alsford S, Kawahara T, Isamah C, Horn D. Alsford S, et al. Mol Microbiol. 2007 Feb;63(3):724-36. doi: 10.1111/j.1365-2958.2006.05553.x. Epub 2007 Jan 4. Mol Microbiol. 2007. PMID: 17214740 Free article.

9

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.

Alsford S, Turner DJ, Obado SO, Sanchez-Flores A, Glover L, Berriman M, Hertz-Fowler C, Horn D. Alsford S, et al. Genome Res. 2011 Jun;21(6):915-24. doi: 10.1101/gr.115089.110. Epub 2011 Mar 1. Genome Res. 2011. PMID: 21363968 Free PMC article.

10

TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei.

Davies C, Ooi CP, Sioutas G, Hall BS, Sidhu H, Butter F, Alsford S, Wickstead B, Rudenko G. Davies C, et al. Among authors: alsford s. Nucleic Acids Res. 2021 Apr 6;49(6):3242-3262. doi: 10.1093/nar/gkab109. Nucleic Acids Res. 2021. PMID: 33660774 Free PMC article.

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