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A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
Dilworth D, Hanley RP, Ferreira de Freitas R, Allali-Hassani A, Zhou M, Mehta N, Marunde MR, Ackloo S, Carvalho Machado RA, Khalili Yazdi A, Owens DDG, Vu V, Nie DY, Alqazzaz M, Marcon E, Li F, Chau I, Bolotokova A, Qin S, Lei M, Liu Y, Szewczyk MM, Dong A, Kazemzadeh S, Abramyan T, Popova IK, Hall NW, Meiners MJ, Cheek MA, Gibson E, Kireev D, Greenblatt JF, Keogh MC, Min J, Brown PJ, Vedadi M, Arrowsmith CH, Barsyte-Lovejoy D, James LI, Schapira M. Dilworth D, et al. Among authors: alqazzaz m. Nat Chem Biol. 2022 Jan;18(1):56-63. doi: 10.1038/s41589-021-00898-0. Epub 2021 Nov 15. Nat Chem Biol. 2022. PMID: 34782742 Free PMC article.
The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.
Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Lester HA, Patapoutian A, Mogil JS. Wieskopf JS, et al. Sci Transl Med. 2015 May 13;7(287):287ra72. doi: 10.1126/scitranslmed.3009986. Sci Transl Med. 2015. PMID: 25972004 Free PMC article.
Cys-loop receptor channel blockers also block GLIC.
Alqazzaz M, Thompson AJ, Price KL, Breitinger HG, Lummis SC. Alqazzaz M, et al. Biophys J. 2011 Dec 21;101(12):2912-8. doi: 10.1016/j.bpj.2011.10.055. Epub 2011 Dec 20. Biophys J. 2011. PMID: 22208189 Free PMC article.
13 results