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Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity.
Ackerman SE, Pearson CI, Gregorio JD, Gonzalez JC, Kenkel JA, Hartmann FJ, Luo A, Ho PY, LeBlanc H, Blum LK, Kimmey SC, Luo A, Nguyen ML, Paik JC, Sheu LY, Ackerman B, Lee A, Li H, Melrose J, Laura RP, Ramani VC, Henning KA, Jackson DY, Safina BS, Yonehiro G, Devens BH, Carmi Y, Chapin SJ, Bendall SC, Kowanetz M, Dornan D, Engleman EG, Alonso MN. Ackerman SE, et al. Among authors: alonso mn. Nat Cancer. 2021 Jan;2(1):18-33. doi: 10.1038/s43018-020-00136-x. Epub 2020 Dec 7. Nat Cancer. 2021. PMID: 35121890 Free PMC article.
Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity.
Carmi Y, Prestwood TR, Spitzer MH, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG. Carmi Y, et al. Among authors: alonso mn. JCI Insight. 2016 Nov 3;1(18):e89020. doi: 10.1172/jci.insight.89020. JCI Insight. 2016. PMID: 27812544 Free PMC article.
Th17 cells induce Th1-polarizing monocyte-derived dendritic cells.
Davidson MG, Alonso MN, Yuan R, Axtell RC, Kenkel JA, Suhoski MM, González JC, Steinman L, Engleman EG. Davidson MG, et al. Among authors: alonso mn. J Immunol. 2013 Aug 1;191(3):1175-87. doi: 10.4049/jimmunol.1203201. Epub 2013 Jun 21. J Immunol. 2013. PMID: 23794631 Free PMC article.
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies.
Winer DA, Winer S, Shen L, Wadia PP, Yantha J, Paltser G, Tsui H, Wu P, Davidson MG, Alonso MN, Leong HX, Glassford A, Caimol M, Kenkel JA, Tedder TF, McLaughlin T, Miklos DB, Dosch HM, Engleman EG. Winer DA, et al. Among authors: alonso mn. Nat Med. 2011 May;17(5):610-7. doi: 10.1038/nm.2353. Epub 2011 Apr 17. Nat Med. 2011. PMID: 21499269 Free PMC article.
B-1a lymphocytes attenuate insulin resistance.
Shen L, Chng MH, Alonso MN, Yuan R, Winer DA, Engleman EG. Shen L, et al. Among authors: alonso mn. Diabetes. 2015 Feb;64(2):593-603. doi: 10.2337/db14-0554. Epub 2014 Sep 23. Diabetes. 2015. PMID: 25249575 Free PMC article.
29 results