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THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates.
Reithuber E, Wixe T, Ludwig KC, Müller A, Uvell H, Grein F, Lindgren AEG, Muschiol S, Nannapaneni P, Eriksson A, Schneider T, Normark S, Henriques-Normark B, Almqvist F, Mellroth P. Reithuber E, et al. Among authors: almqvist f. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2108244118. doi: 10.1073/pnas.2108244118. Proc Natl Acad Sci U S A. 2021. PMID: 34785593 Free PMC article.
Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones.
Andersson EK, Bengtsson C, Evans ML, Chorell E, Sellstedt M, Lindgren AE, Hufnagel DA, Bhattacharya M, Tessier PM, Wittung-Stafshede P, Almqvist F, Chapman MR. Andersson EK, et al. Among authors: almqvist f. Chem Biol. 2013 Oct 24;20(10):1245-54. doi: 10.1016/j.chembiol.2013.07.017. Epub 2013 Sep 12. Chem Biol. 2013. PMID: 24035282 Free PMC article.
Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis.
Flentie K, Harrison GA, Tükenmez H, Livny J, Good JAD, Sarkar S, Zhu DX, Kinsella RL, Weiss LA, Solomon SD, Schene ME, Hansen MR, Cairns AG, Kulén M, Wixe T, Lindgren AEG, Chorell E, Bengtsson C, Krishnan KS, Hultgren SJ, Larsson C, Almqvist F, Stallings CL. Flentie K, et al. Among authors: almqvist f. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10510-10517. doi: 10.1073/pnas.1818009116. Epub 2019 May 6. Proc Natl Acad Sci U S A. 2019. PMID: 31061116 Free PMC article.
Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors.
Kulén M, Núñez-Otero C, Cairns AG, Silver J, Lindgren AEG, Wede E, Singh P, Vielfort K, Bahnan W, Good JAD, Svensson R, Bergström S, Gylfe Å, Almqvist F. Kulén M, et al. Among authors: almqvist f. Medchemcomm. 2019 Oct 17;10(11):1966-1987. doi: 10.1039/c9md00405j. eCollection 2019 Nov 1. Medchemcomm. 2019. PMID: 32206238 Free PMC article.
Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils.
Adolfsson DE, Tyagi M, Singh P, Deuschmann A, Ådén J, Gharibyan AL, Jayaweera SW, Lindgren AEG, Olofsson A, Almqvist F. Adolfsson DE, et al. Among authors: almqvist f. J Org Chem. 2020 Nov 6;85(21):14174-14189. doi: 10.1021/acs.joc.0c01699. Epub 2020 Oct 25. J Org Chem. 2020. PMID: 33099999 Free PMC article.
203 results