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Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights.
Eldehna WM, Maklad RM, Almahli H, Al-Warhi T, Elkaeed EB, Abourehab MAS, Abdel-Aziz HA, El Kerdawy AM. Eldehna WM, et al. Among authors: almahli h. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1227-1240. doi: 10.1080/14756366.2022.2062337. J Enzyme Inhib Med Chem. 2022. PMID: 35470754 Free PMC article.
Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents.
Eldehna WM, Almahli H, Al-Ansary GH, Ghabbour HA, Aly MH, Ismael OE, Al-Dhfyan A, Abdel-Aziz HA. Eldehna WM, et al. Among authors: almahli h. J Enzyme Inhib Med Chem. 2017 Dec;32(1):600-613. doi: 10.1080/14756366.2017.1279155. J Enzyme Inhib Med Chem. 2017. PMID: 28173708 Free PMC article.
Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies.
Al-Warhi T, Abo-Ashour MF, Almahli H, Alotaibi OJ, Al-Sanea MM, Al-Ansary GH, Ahmed HY, Elaasser MM, Eldehna WM, Abdel-Aziz HA. Al-Warhi T, et al. Among authors: almahli h. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1300-1309. doi: 10.1080/14756366.2020.1773814. J Enzyme Inhib Med Chem. 2020. PMID: 32522063 Free PMC article.
Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity.
Tawfik HO, Shaldam MA, Nocentini A, Salem R, Almahli H, Al-Rashood ST, Supuran CT, Eldehna WM. Tawfik HO, et al. Among authors: almahli h. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1043-1052. doi: 10.1080/14756366.2022.2056734. J Enzyme Inhib Med Chem. 2022. PMID: 35437108 Free PMC article.
25 results