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COVID-19 patients display changes in lymphocyte subsets with a higher frequency of dysfunctional CD8lo T cells associated with disease severity.
Onofrio LI, Marin C, Dutto J, Brugo MB, Baigorri RE, Bossio SN, Quiróz JN, Almada L, Ruiz Moreno F, Olivera C, Silvera-Ruiz SM, Ponce NE, Icely PA, Amezcua Vesely MC, Fozzatti L, Rodríguez-Galán MC, Stempin CC, Cervi L; ImmunoCovid-CBA; Maletto BA, Acosta Rodríguez EV, Bertone M, Abiega CD, Escudero D, Kahn A, Caeiro JP, Maccioni M, Motrán CC, Gruppi A, Sotomayor CE, Chiapello LS, Montes CL. Onofrio LI, et al. Among authors: almada l. Front Immunol. 2023 Sep 21;14:1223730. doi: 10.3389/fimmu.2023.1223730. eCollection 2023. Front Immunol. 2023. PMID: 37809093 Free PMC article.
Different cytokine and chemokine profiles in hospitalized patients with COVID-19 during the first and second outbreaks from Argentina show no association with clinical comorbidities.
Almada L, Angiolini SC, Dho ND, Dutto J, Gazzoni Y, Manzone-Rodríguez C, Marín C, Ponce NE, Arroyo DS, Quiróz JN, Iribarren P, Cerbán FM, Morón G, Amezcua Vesely MC, Cervi L, Chiapello LS, Fozzatti L, Icely PA, Maccioni M, Montes CL, Motrán CC, Rodríguez-Galán MC, Stempin CC, Viano ME, Mena C, Bertone M, Abiega CD, Escudero D, Kahn A, Caeiro JP, Maletto BA, Acosta Rodríguez EV, Gruppi A, Sotomayor CE. Almada L, et al. Front Immunol. 2023 Feb 1;14:1111797. doi: 10.3389/fimmu.2023.1111797. eCollection 2023. Front Immunol. 2023. PMID: 36817433 Free PMC article.
Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response.
Serrán MG, Vernengo FF, Almada L, Beccaria CG, Gazzoni Y, Canete PF, Roco JA, Boari JT, Ramello MC, Wehrens E, Cai Y, Zuniga EI, Montes CL, Cockburn IA, Rodriguez EVA, Vinuesa CG, Gruppi A. Serrán MG, et al. Among authors: almada l. Front Immunol. 2022 May 16;13:828734. doi: 10.3389/fimmu.2022.828734. eCollection 2022. Front Immunol. 2022. PMID: 35651611 Free PMC article.
High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity.
Nuñez NG, Schmid J, Power L, Alberti C, Krishnarajah S, Kreutmair S, Unger S, Blanco S, Konigheim B, Marín C, Onofrio L, Kienzler JC, Costa-Pereira S, Ingelfinger F; InmunoCovidCba; InViV working group; Pasinovich ME, Castelli JM, Vizzotti C, Schaefer M, Villar-Vesga J, Mundt S, Merten CH, Sethi A, Wertheimer T, Lutz M, Vanoaica D, Sotomayor C, Gruppi A, Münz C, Cardozo D, Barbás G, Lopez L, Carreño P, Castro G, Raboy E, Gallego S, Morón G, Cervi L, Acosta Rodriguez EV, Maletto BA, Maccioni M, Becher B. Nuñez NG, et al. Nat Immunol. 2023 Jun;24(6):941-954. doi: 10.1038/s41590-023-01499-w. Epub 2023 Apr 24. Nat Immunol. 2023. PMID: 37095378 Free PMC article.
Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of "innate" characteristics during CD8+ T cell development.
Baez NS, Cerbán F, Savid-Frontera C, Hodge DL, Tosello J, Acosta-Rodriguez E, Almada L, Gruppi A, Viano ME, Young HA, Rodriguez-Galan MC. Baez NS, et al. Among authors: almada l. PLoS Pathog. 2019 Jan 4;15(1):e1007456. doi: 10.1371/journal.ppat.1007456. eCollection 2019 Jan. PLoS Pathog. 2019. PMID: 30608984 Free PMC article.
SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer.
Paradise BD, Gainullin VG, Almada LL, Sigafoos AN, Sen S, Vera RE, Raja Arul GL, Toruner M, Pease DR, Gonzalez AL, Mentucci FM, Grasso DH, Fernandez-Zapico ME. Paradise BD, et al. Among authors: almada ll. Biochem J. 2023 Aug 16;480(15):1199-1216. doi: 10.1042/BCJ20220439. Biochem J. 2023. PMID: 37477952
Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML.
Letson CT, Balasis ME, Newman H, Binder M, Vedder A, Kinose F, Ball M, Kruer T, Quintana A, Lasho TL, Finke CM, Almada LL, Grants JM, Zhang G, Fernandez-Zapico ME, Gaspar-Maia A, Lancet J, Komrokji R, Haura E, Sallman DA, Reuther GW, Karsan A, Rix U, Patnaik MM, Padron E. Letson CT, et al. Among authors: almada ll. Clin Cancer Res. 2023 Aug 1;29(15):2919-2932. doi: 10.1158/1078-0432.CCR-22-3929. Clin Cancer Res. 2023. PMID: 37223910 Free PMC article.
GLI1, a novel target of the ER stress regulator p97/VCP, promotes ATF6f-mediated activation of XBP1.
Almada LL, Barroso K, Sen S, Toruner M, Sigafoos AN, Raja Arul GL, Pease DR, Vera RE, Olson RLO, Auner HW, Pedeux R, Iovanna JL, Chevet E, Fernandez-Zapico ME. Almada LL, et al. Biochim Biophys Acta Gene Regul Mech. 2023 Jun;1866(2):194924. doi: 10.1016/j.bbagrm.2023.194924. Epub 2023 Feb 25. Biochim Biophys Acta Gene Regul Mech. 2023. PMID: 36842643 Free article.
72 results